A Bruker Console Upgrade for the OHSU Advanced Imaging Research Center 11.7T MRI

项目摘要/摘要 俄勒冈健康与科学大学(OHSU)高级成像研究中心(AIRC)成立 在2003年提供最先进的磁共振仪器和专家技术支持 OHSU研究界的科学。该中心现在支持四个高端研究专用核磁共振 仪器包括两台全身3特斯拉(T)西门子Prisma扫描仪，一台大口径(90厘米)7T 西门子Magnetom和一台直径31厘米的布鲁克小动物仪器。其中三种乐器是 位于侯爵山上的俄亥俄州立大学主校区，俯瞰波特兰市中心，是 3T核磁共振仪器位于俄勒冈州国家灵长类动物园区的卫星AIRC设施中 研究中心(ONPRC)。这些工具中的每一个都有相当大的能力来产生大量的 数据，使研究人员能够在疾病的小动物/大动物模型和临床之间无缝地工作 研究并通过这样做，促进我们对人类疾病根源的理解。最终，我们 期待OHSU社区产生的磁共振数据在 为许多疾病状态开发新的预防、早期诊断和干预方法。 然而，图像质量、时间分辨率、扫描环境和维护方面的问题是必要的 为了保持这一领域的生产力，需要升级我们已有16年历史的11.7T小动物核磁共振仪器。 本申请的主题是申请资金，将我们目前的Bruker Avance II升级到Bruker A 布鲁克Avance NEO控制台。我们目前的仪器自2006年以来一直在运行，并支持更多 20多名调查人员，许多初级教员通过联邦机构资助的项目，并计划进行一项大规模的 随着我们的前进，新研究的数量也在增加。拟议的升级将提供亟需的改进 在梯度性能、数据采集速度、时间稳定性、改进的工作流程和后处理方面 功能(数据访问、图像重建、计算)和减少停机时间；这些功能将 对正在进行的和新提出的研究有实质性的好处。

Project Summary/Abstract The Oregon Health & Science University (OHSU) Advanced Imaging Research Center (AIRC) was established in 2003 to provide access to state-of- the-art instruments and expert technical support in magnetic resonance science to the OHSU research community. The Center now supports four high-end research-dedicated MRI instruments that includes two whole-body 3 Tesla(T) Siemens Prisma scanners, a large-bore (90cm) 7T Siemens Magnetom, and a 31 cm bore 11.7T Bruker small animal instrument. Three of the instruments are located on the main OHSU campus located on Marquam Hill, overlooking downtown Portland, and one of the 3T MRI instruments is located at a satellite AIRC facility on the campus of the Oregon National Primate Research Center (ONPRC). Each of these instruments has substantial capability to generate large amounts of data, allows investigators to work seamlessly between small/large animal models of disease and clinical studies and, in doing so, advance our understanding of the root causes of human disease. Ultimately, we expect the magnetic resonance data generated by the OHSU community to play a pivotal role in the development of new methods of prevention, early diagnosis and intervention for many disease states. However, the image quality, temporal resolution, scanning environment, and maintenance concerns necessary to remain productive in this area requires that our 16 year old 11.7T small animal MRI instrument be upgraded. The subject of this application is to request funds for an upgrade of our current Bruker AVANCE II to a Bruker a Bruker AVANCE NEO console. Our current instrument has been in operation since 2006 and supports more than 20 investigators, many junior faculty with projects funded through federal agencies, and plans for a large number of new studies as we move forward. The proposed upgrade will provide much needed improvements in gradient performance, data acquisition speed, temporal stability, improved workflow, and post-processing capabilities (data access, image reconstruction, calculation) and reduced downtime; capabilities that will substantially benefit on-going and newly proposed studies.