Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)

TEXAS BIOMED IN-TRAC总体摘要 德克萨斯州生物医学研究所跨学科NexGen TB研究促进中心（IN-TRAC） 研究所（得克萨斯州生物医学）将吸引下一代不同的研究人员对结核病（TB）的研究 领域，并将他们培养成具有多学科技能和现实世界经验的独立研究人员， 临床结核病IN-TRAC的产品将是研究人员，他们选择从事一些最具挑战性的工作， 以及结核病的相关转化问题，并在跨学科和 高度合作的研究。这将通过6个相互关联的核心来实现。行政核心：The 核心预算资源调拨目标管理和监督中心，负责行政和科学方面的工作， 领导;协调核心，研究人员和NIH/NIAID计划工作人员之间的沟通， 提供一个组织结构，以优化多学科合作和互动之间的 核心和各种各样的IN-TRAC参与者。发展核心：监督所有职业生涯 发展规划和课程，量身定制的研究和临床经验，无论是实习生和 （c）向每一个核心预算资源调拨目标参与者提供实习机会，并管理核心预算资源调拨目标试点赠款方案。 生物安全和生物遏制核心：将所需的生物安全培训扩展到个性化课程 包括理论和实践生物遏制培训，了解机械和监管 BSL 3/ABSL 3的要求，指导如何制定生物安全协议，并通过风险工作 从生物安全官员的角度进行评估。研究成像核心：提供理论和 单细胞成像的实践培训（共聚焦显微镜、细胞计数、活细胞成像、单细胞RNAseq） 到小鼠（IVIS）和非人灵长类动物（NHP）（PET/CT）的全身成像， 配备BSL 3/ABSL 3设施。动物模型核心：实施培训计划，介绍所有IN-TRAC 参与者对啮齿动物和NHP的监管要求，如何制定一个强大的 实验方案，如何编写IACUC方案，以及动手动物处理和实验 程序.临床研究和患者护理核心：将IN-TRAC参与者介绍给结核病患者护理， 美国唯一一家独立的结核病医院（德克萨斯州传染病中心）， 最具挑战性的结核病病例。与此合作的将是美国的临床研究经验- 墨西哥边境，在服务不足和资源不足的社区进行结核病研究。

TEXAS BIOMED IN-TRAC OVERALL ABSTRACT The Interdisciplinary NexGen TB Research Advancement Center (IN-TRAC) at Texas Biomedical Research Institute (Texas Biomed) will attract the next generation of diverse researchers to the tuberculosis (TB) research field, and develop them into independent researchers with multi-disciplinary skills and real-world experience of clinical TB. The product of IN-TRAC will be researchers that choose to work on some of the most challenging and relevant translational problems in TB, and that work across academic disciplines and within a framework of highly collaborative research. This will be achieved through 6 interrelated Cores. Administrative Core: The central hub of IN-TRAC management and oversight, with responsibility for administrative and scientific leadership; coordinating communication between Cores, researchers and NIH/NIAID Program staff and providing an organizational structure to optimize multidisciplinary collaborations and interactions between the Cores and among a diverse cohort of IN-TRAC participants. Development Core: Oversight of all career development programming and courses, tailoring the research and clinical experiences, both intern and externships, to each individual IN-TRAC participant, and management of the IN-TRAC pilot grant program. Biosafety & Biocontainment Core: Extending the required biosafety training to a personalized curriculum including theoretical and hands-on biocontainment training, understanding the mechanical and regulatory requirements of a BSL3/ABSL3, coaching on how to develop biosafety protocols, and working through risk assessments from the perspective of a Biosafety Officer. Research Imaging Core: Providing theoretical and hands-on training from single cell imaging (confocal microscopy, cytometry, live cell imaging, single cell RNAseq) through to whole body imaging in mice (IVIS) and Non-human primates (NHP) (PET/CT) within large, fully outfitted BSL3/ABSL3 facilities. Animal Model Core: Implementing a training program to introduce all IN-TRAC participants to the regulatory requirements for working with rodents and NHPs, how to develop a robust experimental protocol, how to write an IACUC protocol, and hands-on animal handling and experimental procedures. Clinical Research & Patient Care Core: Introducing IN-TRAC participants to TB patient care at the only free-standing TB hospital in the US (Texas Center of Infectious Diseases) that manages some of the most challenging cases of TB nationally. Partnering with this will be a clinical research experience at the US- Mexico border, to experience TB studies in under-served and under-resourced communities.