Tau Burden and Spatial Spread in Preclinical Alzheimer Disease

项目1：项目概要/摘要 成人儿童研究（ACS）是一项正在进行的评估中老年人的发展风险， 阿尔茨海默病（AD）。在ACS的项目1中，我们使用先进的成像技术组合， 探索AD病理学的最早迹象。使用正电子发射断层扫描（PET），我们测试淀粉样蛋白， 使用匹兹堡化合物B C11（PiB）和Flortaucipir F18（FTP），我们研究了tau蛋白在脑中的沉积， 使用磁共振成像（MRI）检查大脑结构网络、病理学和生理学。而 淀粉样蛋白沉积可以在痴呆症状出现前20年出现，tau蛋白沉积与痴呆症状密切相关。 认知能力下降我们将评估大脑中的结构和功能变化与 从AD的无症状（临床前）阶段过渡到AD痴呆的有症状阶段。我们 将为每种成像方式生成独特的大脑地图，然后我们将检查这些地图与 彼此，以发展在过渡期间发生的成像变化的综合理解 无症状和有症状的AD。我们将联合收割机与生活方式的信息相结合， 在其他ACS核心中获得的运动、饮食、炎症以及血液和脑脊液（CSF）检查 和项目，以便更好地了解哪些因素导致AD痴呆症。

Project 1: Project Summary/Abstract The Adult Children Study (ACS) is an ongoing evaluation of middle to older adults at risk for development of Alzheimer disease (AD). In Project 1 of the ACS, we use a combination of advanced imaging techniques to explore the earliest signs of AD pathology. Using positron emission tomography (PET) we test for amyloid and tau protein deposits in the brain, using Pittsburgh Compound B C11 (PiB) and Flortaucipir F18 (FTP) and we examine brain structural networks, pathology and physiology using magnetic resonance imaging (MRI). While amyloid deposits can be present up to 20 years before dementia symptoms, tau deposits are closely linked with cognitive decline. We will evaluate the structural and functional changes in the brain associated with the transition from the asymptomatic (preclinical) phase of AD into the symptomatic stages of AD dementia. We will generate unique brain maps for each imaging modality and we will then examine these maps in relation to one another, to develop an integrated understanding of the imaging changes which occur during the transition from asymptomatic and symptomatic AD. We will combine this information with information about lifestyle, exercise, diet, inflammation, and blood and cerebrospinal fluid (CSF) tests obtained in the other ACS Cores and Projects in order to better understand what factors lead to AD dementia.