Deriving a de novo adolescent addiction treatment from developmental brain data

项目总结 费尔德斯坦·尤因博士正在申请职业中期调查员奖(K24)，以支持她的发展 青少年酒精治疗的创新性、转化性(临床+影像)研究。K24将保护 是时候为她对新兴调查人员的指导提供便利了。她的职业发展和培训目标是 与提前计划的研究目标紧密和协同地联系在一起。费尔德斯坦·尤因博士的5-10年研究 计划是为与毒瘾作斗争的青少年开发更有效的治疗方法。费尔德斯坦·尤因博士 认为这一领域的进步最有可能来自于直接质疑 发展中的大脑，旨在量身定做针对特定时期的明确干预措施 神经发育的影响。青少年成瘾的翻译研究是非常耗费人力的。K24研究 资金是必要的，以便为费尔德斯坦·尤因博士提供保护时间，使其免受临床和 行政职责，在这种类型的医院/医疗保健环境中，这通常是高度耗时的，但 不幸的是，不能推进研究、培训或指导。因此，在此范围内可用的保护时间 这一机制将准确地促进将调查员解放到 了解更多关于青少年精神病理学、青少年学习和教育领域的现有干预措施 内存和高级量化方法，可以用来最大限度地利用现有数据 已经在为高需求青少年开发新的干预措施方面推动了这一领域的发展 与毒瘾作斗争。这种保护还将为费尔德斯坦·尤因博士获得受保护的时间提供便利 并让学员参与到这一过程的每一个阶段。与许多其他学术医学培训中心一样， 如果没有K24，费尔德斯坦博士将无法获得这种受保护的研究/培训时间 尤因。在一个关键时刻，这一报道对于推进青少年治疗的创新至关重要 完成这项工作的资源和机会是可用的。这是一个非常有兴趣和需求的领域。 对于NIAAA来说；这个K24奖将启动一个新的科学家领域，在这个领域开始真正的进展 青少年酒精与成瘾研究及其干预。

PROJECT SUMMARY Dr. Feldstein Ewing is applying for a Mid-Career Investigator Award (K24) to support her development of innovative, translational (clinical + imaging) research in adolescent alcohol treatment. The K24 would protect time to facilitate her mentorship of emerging investigators. Her career development and training aims are tightly and synergistically linked to advance planned research aims. Dr. Feldstein Ewing's 5-10 year research plan is to develop more efficacious treatment for adolescents who struggle with addiction. Dr. Feldstein Ewing believes that advances from this area are most likely to stem from integrative approaches that directly query the developing brain, and aims to tailor articulated interventions that are responsive to that very specific period of neural development. Translational research in adolescent addiction is very labor intensive. K24 research funding is requisite to provide Dr. Feldstein Ewing with protected time from the call of clinical and administrative duties, which in this type of hospital/medical care setting are often highly time intensive, but unfortunately do not advance research, training, or mentorship. Thus, protected time available within this mechanism would facilitate precisely the type of protected coverage requisite for freeing up the investigator to learn more about existing interventions in the field of adolescent psychopathology, adolescent learning and memory, and advanced quantitative methods that can be used to maximize existing data that the candidate already has, to propel the field forward in terms of developing novel interventions for high-need adolescents struggling with addiction. This protection would also facilitate protected time for Dr. Feldstein Ewing to engage and involve mentees at every stage of this process. As with many other academic medical training centers, without this K24, this type of protected research/training time will not otherwise be available to Dr. Feldstein Ewing. This coverage is crucial for advancing innovations in adolescent treatment, at a critical juncture where the resources and opportunity are available for this work to be done. This is a high area of interest and need for NIAAA; this K24 award would launch a new field of scientists to start true progress in this domain of adolescent alcohol and addiction research, and its intervention.