PET imaging of presynaptic nigrostriatal dopaminergic function in optimally treated HIV+ patients

我们已获得IRB批准，于2018年7月开始招募患者。我们于2018年11月20日开始成像。我们已经招募了总共38名受试者，他们接受了一次扫描（仅FDOPA扫描，n=1，仅DASB扫描，n=2）或两次扫描（FDOPA和DASB， n= 35）。

We have received IRB approval to start recruiting patients in July 2018. We started imaging on 11/20/2018. We have already recruited a total of 38 subjects who have undergone one scan (Only FDOPA scan, n=1, only DASB scan, n=2) or two scans (FDOPA and DASB, n= 35) Imaging the dopaminergic system: 1. Group A: 18 patients with HIV infection 2. Group B: 11 subjects without HIV infection with at least one co-morbidity 3. Group C: 8 patients without HIV infection without co-morbidities. Imaging of the Serotonin transporter (SERT using 11C-DASB). 1. Group D: 16 patients with HIV infection. 2. Group E: 20 patients without HIV infection. Updates: there was a long period of hiatus where we could not include subjects due to the covid epidemic. We started recruiting patients again in late 2020. We have since amended our protocol to be able to recruit subjects from other NIH intramural protocols other than the all hands protocol. This necessitated adding MRI and neuropsychological testing to the protocol for those subjects. Data analysis: we are currently analyzing the data (operator blinded for the group) namely quantifying FDOPA and DASB uptake in the brain of all our subjects. We are hoping to finalize recruitment and perform a final analysis in early to mid 2022.