Core 1: Administrative Core

核心1：项目概要管理核心（核心1）是耶鲁皮肤癌孢子（YSPORE）成功的关键。核心的主要目的是支持和促进皮肤癌的跨学科研究工作，并确定新的挑战和机遇，因为它们出现。管理核心作为YSPORE研究者的中心协调点，负责监测所有项目和核心朝着转化/临床终点的进展。这些服务包括提供（a）财务管理，（B）文书和组织支持，（c）内部和外部审查机制，（d）支持加强项目/核心领导人之间的科学互动和合作，（e）监测项目和核心科学进展的机制，（f）协调外联工作，以及（g）在耶鲁大学内外，将皮肤癌研究扩展到孢子活动之外的机制。核心1还将负责确保耶鲁大学皮肤癌研究中心的活动与耶鲁大学癌症中心的活动充分整合，目标是避免工作重叠和重复，同时最大限度地发挥协同作用和利用资源。SPORE调查人员之间可能出现的任何冲突将由核心1董事解决，并在必要时由执行委员会、外部和内部咨询委员会以及Charles Fuchs医学博士提供意见。核心1将与生物信息学和生物统计学核心（核心3）密切合作，以确保将SPORE项目生成的数据整合到耶鲁癌症中心的数据中，反之亦然，并监督与其他皮肤癌/黑色素瘤SPORE研究中心的数据共享，并在适当时与耶鲁肺癌SPORE共享数据。由Core 1组织的联合科学研究进展会议将与SPORE研究人员举行，以确保思想的双向流动和资源的共享。参与该项目的研究者还将参加由核心1与其他研究中心的行政核心合作组织的年度SPORE间研讨会。YSPORE在康涅狄格州纽黑文举办了2017年Inter-SPORE研讨会。核心将由Marcus Bosenberg博士和哈里特Kluger博士指导，联合主任是Mario Sznol博士。核心1的计划监督将在执行委员会的投入下完成，科学和行政职能的投入将从内部和外部咨询委员会寻求。核心1将组织与内部和外部咨询委员会的年度会议。核心还将组织研究进展研讨会，外部调查人员的会谈，以及患者和社区外展。

CORE 1: PROJECT SUMMARY The Administrative Core (Core 1) is critical to the success of the Yale SPORE in Skin Cancer (YSPORE). The primary purpose of the Core is to support and facilitate transdisciplinary research efforts in skin cancer and identify new challenges and opportunities as they emerge. The Administrative Core serves as the central coordination point for YSPORE investigators, with responsibility for monitoring the progress of all projects and cores toward a translational/clinical endpoint. These services include provision of (a) fiscal management, (b) clerical and organizational support, (c) mechanisms for internal and external review, (d) support for enhancement of scientific interactions and collaborations among the Project/Core leaders, (e) mechanisms to monitor projects and cores for scientific progress, (f) coordination of outreach efforts, and (g) mechanisms to expand research in skin cancer beyond the activities of the SPORE, both within Yale and outside of Yale. Core 1 will also be responsible for ensuring full integration of activities of the Yale SPORE in Skin Cancer with those of Yale Cancer Center, with the goal of avoiding overlap and duplication of efforts while maximizing synergy and use of resources. Any conflicts that might arise between SPORE investigators will be addressed by the Core 1 Directors, with input from the Executive Committee and the External and Internal Advisory Boards and Charles Fuchs, MD if needed. Core 1 will work closely with the Bioinformatics and Biostatistics Core (Core 3) to ensure the integration of data generated by the SPORE program into that of Yale Cancer Center and vice versa, and to oversee sharing of data with other skin cancer/melanoma SPORE sites, and when appropriate, with the Yale SPORE in Lung Cancer. Joint scientific research in progress meetings will be held with the SPORE researchers, organized by Core 1, to ensure bi-directional flow of ideas and sharing of resources. Investigators involved in this program will also participate in the annual inter-SPORE workshops, organized by Core 1 in collaboration with Administrative Cores at other sites. YSPORE hosted the 2017 inter-SPORE workshop in New Haven, CT. The Core will be directed by Drs. Marcus Bosenberg and Harriet Kluger and the Co-Director is Dr. Mario Sznol. Program oversight by Core 1 will be done with input from the Executive Committee, and input for scientific and administrative functions will be sought from the Internal and External Advisory Boards. Annual meetings with the Internal and External Advisory Boards will be organized by Core 1. The Core will also organize research in progress seminars, talks by outside investigators, and patient and community outreach.