P300 SYMPTOMS AND THE TEMPORAL LOBE IN SCHIZOPHRENIA

有几种建议认为精神分裂症可能与 颞叶的异常。许多精神分裂症患者都有异常 P300听觉诱发对音调的反应以及为此产生的神经发生器 听觉诱发反应也可以定位于颞叶， 这表明精神分裂症患者颞叶的异常可能 与临床症状和电生理表现有关。 我们建议研究P300、TIMAL之间的相互关系 叶结构(通过磁共振成像测量)和阳性 精心配对的精神分裂症患者和正常人群的症状测量 控制。 这项研究将与神经学的基础科学研究相关 P300的基础以及有助于理解两者之间的联系 P300异常和精神分裂症症状。

There are several suggestions that schizophrenia may be associated with abnormalities in the temporal lobes. Many schizophrenics have abnormal P300 auditory evoked responses to tones, and the neural generator for this auditory evoked response may also be localized in the temporal lobes, suggesting that abnormalities in the temporal lobes of schizophrenics may be related to both clinical symptoms and electrophysiologic findings. We propose to examine the interrelationships between the P300, temporal lobe structures (measured by magnetic resonance imaging) and positive symptom measures in a carefully matched group of schizophrenics and normal controls. The study will be relevant to both basic science research on the neural basis of the P300 as well as help in understanding the connection between P300 abnormalities and schizophrenic symptoms.