NEURAL MECHANISMS OF HEARING AND BALANCE

这个项目的目标是研究神经和细胞的基础 鱼的迷路功能，因为它们与平衡和 听证。蟾鱼，Opsanus tau将提供一个模型系统。我们将使用 视频显微镜和图像分析技术在杯状力学研究中的应用 和细观力学对充分刺激的反应进行评价 杯状回对传入反应的形成可能有贡献 将对蟾鱼的实际顶盖-内淋巴系统进行建模。我们会研究 毛细胞对立体纤毛运动的感受器电流 位于克里斯塔的中心和外围。传出对…的影响 位于中央和外围的毛细胞也将被记录在案。 我们计划对球囊和椭圆形功能进行平行研究。这个 对蟾鱼的脑干和迷路的研究相对较多。在鱼中， 声音由一个或多个耳石器官的毛细胞传递。 它们充当听觉接收器，在适当的 频谱。我们将采用半圆形开发的技术 运河研究对鱼类的听力器官进行调查。这些措施包括 中枢神经系统的慢性和急性记录及形态生理学研究 初级传入神经的外周投射。我们将评估这一角色 球囊和椭圆形在声音接收中的作用 在声音刺激时传入。推定的中心投射 声音接收器官，主要是球囊和椭圆形，占据区域。 前庭相对游离的八头肌前核的 输入。我们将继续进行形态学研究，以描绘出听觉 前庭脑干区。颈椎病的中枢和外周形态 将对单个传入进行研究，以确定是否存在特定的 感受器器官区域处理声音与前庭感觉和 以确定大脑中可能处理声音的共同区域。

The goals of this project are to study the neural and cellular bases of labyrinthine function in the fish as they relate to equilibrium and hearing. Toadfish, Opsanus tau will provide a model system. We will use video microscopy and image analysis techniques to study cupular mechanics and micromechanics in response to adequate stimulation to evaluate possible cupular contributions to the shaping of afferent responses and will model the actual cupula-endolymph system of toadfish. We will study receptor currents in response to stereociliary movement in hair cells located in the center and periphery of the crista. Efferent effects upon centrally and peripherally located hair cells will also be documented. We plan parallel studies of saccular and utricular function. The brainstem and labyrinth of toadfish ar relatively well studied. In fish, sound is transduced by hair cells of one or more of the otolithic organs that act as auditory receivers to operate within the appropriate frequency spectrum. We will employ techniques developed in semicircular canal studies to investigate the hearing organs of fish. These include chronic and acute recording and morphophysiological studies of central and peripheral projections of primary afferent. We will assess the role of the saccule and utricle in sound reception by recording from their afferent during sound stimuli. The central projections of the putative sound receiving organs, primarily the saccule and utricle, occupy areas of the anterior octavus nucleus that is relatively free of vestibular input. We will continue morphological studies to delineate auditory from vestibular brainstem areas. The central and peripheral morphology of single afferent will be studied to determine if there are specific receptor organ regions that process sound versus vestibular sensation and to specify possible common areas of the brain that process sound.