CHICAGO MINORITY TYPE I DIABETES REGISTRY

糖尿病被广泛认为是非洲人的主要健康问题 在美国的美国人和拉美裔人。相对较少的关注 然而，儿童糖尿病是这一问题的一个组成部分。 尽管患胰岛素依赖型糖尿病(IDDM)的风险 普遍认为在少数族裔儿童和青少年中较低 在非西班牙裔白人中，有证据表明相关的 发病率和死亡率很可能会增加。I型糖尿病是一种 儿童时期的重要疾病，因为它的相对患病率、成本 终生治疗的风险，以及并发症和 过早死亡。关于描述性的知识库 美国黑人和城市拉美裔人群中IDDM的流行病学研究 国家仍然很弱，在很大程度上是因为没有 试图组织对人群中多种风险因素的研究 有足够大小的中心。因此，我们提出了以人口为基础的 芝加哥黑人和拉丁裔儿童糖尿病患者登记处。这个 芝加哥大都市区是大量非裔美国人的家园 和西班牙裔以及其他移民群体，并提供了一个独特的 有机会研究这些少数民族的糖尿病发病率模式 人口。只有掌握了基本的发病数据，才会尝试 延迟或预防少数族裔儿童的并发症，并解决 这种疾病的社会代价，将变得可行。 来自该注册表的数据将允许评估 黑人和西班牙裔人患IDDM的风险。具体地说，建议的 研究将：1)追溯确定IDDM的发病率 1985年到1990年，预期到1995年，黑人和西班牙裔儿童 在伊利诺伊州芝加哥，未满18周岁；2)考试 按社会经济地位划分的族裔群体内的发病率；3)确定 IDDM的发病率因性别、年龄或季节而异。 年，以及发病率是否上升、下降或 在研究期间保持稳定；以及4)确定 拉美裔人群中IDDM的发病率因地域而异 原产地和存在的遗传混合程度。 一旦建立了登记人口，将进行进一步的研究 疾病的自然病史和评估护理质量 少数族裔人口。具体的研究问题将解决某些 少数民族患者中IDDM的遗传关联、家族性模式 IDDM的聚集以及疾病对社会和财政的影响 少数族裔家庭。

Diabetes is widely recognized as a major health concern among African Americans and Hispanics in the U.S. Relatively little attention has been directed to childhood diabetes as a component of this problem, however. Although the risk of insulin-dependent diabetes mellitus (IDDM) is generally thought to be lower among minority children and adolescents than among non-Hispanic whites, there is evidence that the associated morbidity and mortality may well be increased. Type I diabetes is an important disease of childhood due to its relative prevalence, the costs of lifelong treatment, and the long term risks for complications and premature mortality. The knowledge base regarding the descriptive epidemiology of IDDM among blacks and urban Hispanics in the United States remains very weak, in large measure because there have been no attempts to organize studies on multiple risk factors in a population center of sufficient size. Therefore we propose a population-based registry of black and Latino childhood diabetes patients in Chicago. The Chicago metropolitan area is home to large numbers of African-Americans and Hispanics, as well as other immigrant groups, and provides a unique opportunity to study the patterns of diabetes incidence in these minority populations. It is only with basic incidence data in hand that attempts to delay or prevent complications among minority children and to address the social costs of the disease, will become feasible. The data from this registry will allow the evaluation of differences in risk for IDDM in blacks and Hispanics. Specifically, the proposed research will: 1) determine the incidence of IDDM retrospectively from 1985 to 1990, and prospectively to 1995, in black and Hispanic children under the age of 18 in the city of Chicago, Illinois; 2) examine incidence within ethnic groups by socioeconomic status; 3) determine if the incidence of IDDM varies by sex, by age, or by the season of the year, and whether the incidence rate has increased, decreased, or has remained stable over the study period; and 4) determine whether the incidence of IDDM among Hispanic populations varies with geographic location of origin and with the degree of genetic admixture present. Once the registry population is established, further studies will assess the natural history of the disease and evaluate the quality of care for minority populations. Specific research questions will address certain genetic associations with IDDM in minority patients, patterns of familial aggregation of IDDM and the social and financial impact of the disease on minority families.