HETEROCYCLE-METAL PI COMPLEXES IN ORGANIC SYNTHESIS

关于对映体和区域特异性的新的一般战略 构建具有药用价值的分子(抗病毒药物、抗生素、 抗肿瘤药物等)对美国国立卫生研究院的总体任务非常重要。 区域和对映体特异性检测新方法的发展 高取代杂环(二氢和双环)的合成 描述了四氢吡喃、呋喃、哌啶和吡咯)。这 提案将强调在有机合成中的各种用途 取代杂环金属pi-配合物(eta4-，eta2-，eta3-2H-呋喃 和吡咯；eta5-、eta3-、eta4-2H-吡喃和吡啶) 碳水化合物前体以提供其对映体纯的衍生物 上述类别的化合物。成功地实现了这一点 新策略将引入一种新的合成方法 一类重要的杂环有机化合物 在各种检测中的生物活性(抗病毒、抗生素、 等)。

New and general strategies for the enantio- and regiospecific construction of molecules of medicinal interest (antivirals, antibiotics, antitumor agents, etc.) are important to the overall mission of the NIH. The development of new methods for the regio- and enantiospecific synthesis of highly substituted heterocycles (dihydro- and tetrahydropyrans, furans, piperidines and pyrroles) is described. This proposal will emphasize the use in organic synthesis of various substituted heterocycle-metal pi-complexes (eta4-, eta2-, eta3-2H-furan and pyrrole; eta5-, eta3-, eta4-2H-pyran and pyridine) derived from carbohydrate precursors to provide enantiomerically pure derivatives of the above mentioned classes of compounds. Successful achievement of this new strategy would introduce a novel method for the synthesis of important classes of heterocyclic organic compounds with demonstrated biological activity in a wide variety of assays (antiviral, antibiotic, etc.).