Tags and algorithms for studies of protein structures and interactions

该项目旨在开发一套新的工具来结构表征蛋白质-蛋白质和蛋白质-配体相互作用，这些相互作用很难或不可能通过其他方法进行分析，促进生物材料中蛋白质的跟踪并识别相互作用伙伴。该项目旨在专注于合成新的非天然氨基酸和用于特定位点蛋白质标记的标签，以及一系列用于溶液中3D结构分析的技术，特别是核磁共振波谱。新的算法有望从稀疏数据中优化核磁共振波谱和结构计算。集成的工具集有望提供更好和更快的结构分析和目标表征，以加速药物发现的早期阶段。

This project aims to develop a new set of tools to structurally characterise protein-protein and protein-ligand interactions that are difficult or impossible to analyse by other means, facilitate tracking of proteins in biological material and identify interaction partners. The project seeks to focus on the synthesis of new unnatural amino acids and tags for site-specific protein labelling, and a range of techniques for 3D structure analysis in solution, in particular NMR spectroscopy. New algorithms are expected to be developed for optimizing NMR spectroscopy and structure calculations from sparse data. The integrated set of tools is expected to deliver better and faster structure analysis and target characterisation to accelerate early stages of drug discovery.