BRAIN MONOAMINES AND CONDITIONED BEHAVIOR

这项拟议研究的最终目标是理解 脑神经递质系统在脑血管紧张素转换酶活性中的作用 精神药物和行为的维持。这个 研究将集中在多巴胺的行为参与上， 去甲肾上腺素和5-羟色胺。行为将被衡量 使用计算机控制的实时数据应用系统。这个 研究将采用两种密切相关的平行方法。在……里面 第一种方法，一种敏感而具体的操作行为 将使用检测具有抗抑郁作用的药物的筛查 对儿茶酚胺和5-羟色胺能组分的测定 抗抑郁药物的作用。此外，还将进行研究，以 确定去甲肾上腺素、多巴胺和5-羟色胺 系统相互作用，产生抗抑郁效果。的目标是 这项研究是为了阐明神经化学变化 调节抗抑郁药物对操作者行为的影响。知识 这些神经化学变化可以提供对 抑郁症的病理生理学。对于第二种方法，研究 将会被用来确定神经化学机制 药物、行为和环境之间的相互作用。药效 对行为的影响不仅取决于特定的药物和剂量 药物的大小，还取决于药物所处的环境 对正在进行的行为进行控制。因此， 神经化学变化将作为以下因素的函数进行测量 系统地改变环境和行为参数。 独立的环境和行为参数知识 改变大脑化学的变量将提供额外的 对精神疾病的病理生理学的洞察。

The ultimate goal of this proposed research is to understand the role of brain neurotransmitter systems in the actions of psychotropic drugs and in the maintenance of behavior. The research will focus on the behavioral involvement of dopamine, norepinephrine, and 5-hydroxytryptamine. Behavior will be measured using a computer-controlled real-time data application system. The research will employ two closely related parallel approaches. In the first approach, a sensitive and specific operant behavioral screen that detects drugs with antidepressant action will be used to determine the catecholaminergic and serotonergic components of antidepressant drugs effects. Also, studies will be done to determine whether norepinephrine, dopamine and 5-hydroxytryptamine systems interact to produce antidepressant effects. The goal of this research is to elucidate the neurochemical changes that mediate antidepressant drug effects on operant behavior. Knowledge of these neurochemical changes could provide insight into the pathophysiology of depression. For the second approach, studies will be done to determine the neurochemical mechanisms that mediate interactions between drugs, behavior and the environment. Drug effects on behavior depend not only on the specific drug and dose of the drug, but also depend on the environment in which the drug is administered and on the ongoing behavior. Therefore, neurochemical change will be measured as a function of systematically varied environmental and behavioral parameters. Knowledge of environmental and behavioral parameters as independent variables that alter brain chemistry would provide additional insight into the pathophysiology of mental illness.