Microstructural-Functional Effect of Silver Diammine Fluoride on Apatites

该项目旨在在纳米结构水平上对导致二胺氟化银（SDF）处理后牙本质和牙釉质矿化和机械性能增强的因素有一个基本的了解。各种先进的纳米机械、层析成像和显微技术将用于表征健全、龋齿和SDF处理的组织。新的生物力学证据的潜在机制，替代方案，给药系统能够优化治疗。阻止/修复损伤过程的科学见解将为制定针对儿科和老年人群的最小干预方案提供关键数据。

This project aims to develop a fundamental understanding at the nanostructural level of the factors that contribute to the enhanced mineralisation and mechanical properties of dentine and enamel following the treatment with silver diammine fluoride (SDF). A variety of advanced nanomechanical, tomographic and microscopic techniques will be used to characterise sound, carious and SDF treated tissue. The new biomechanical evidence on the underlying mechanisms, alternative protocols, delivery systems enable to optimise the treatment. The scientific insights into arresting/repairing damage processes will provide critical data for developing minimal intervention protocols for pediatric and geriatric populations.