PRECHRONIC AND CHRONIC TOXICITY STUDY OF NITROMETHANE

这个项目的目标是描述剂量反应的特征 硝基甲烷给药的关系及毒性 大鼠和小鼠吸入14天、90天重复给药 亚慢性和2年慢性研究。动物将被暴露在 每天6小时，每周5天，连续14天和90天或2天 好几年了。在每项研究结束时，所有动物都将被给予大体观察。 以及显微镜下的组织病理学检查。血液学，临床 化学、精子形态和阴道细胞学检查 在为期90天的研究中。65周的临时牺牲，包括 慢性病患者将进行血液学和组织病理学检查。 学习。NTP将使用每项研究的结果来确定 下一项研究中使用的剂量(即14天的结果 90天的研究；慢性研究的90天结果)。

The objective of this project is to characterize dose-response relationships and toxicity of nitromethane administered by inhalation to rats and mice in 14-day repeated-dose, 90-day subchronic and 2-year chronic studies. Animals will be exposed for 6 hours per day, 5 days per week for 14 and 90 days or 2 years. At the end of each study, all animals will be given gross and microscopic histopathologic evaluations. Hematology, clinical chemistry, and sperm morphology/vaginal cytology will be performed in the 90-day study. A 65-week interim sacrifice, including hematology and histopathology will be performed in the chronic study. The results of each study will be used by NTP to establish doses to be used in the next study (i.e., the 14-day results for the 90-day study; the 90-day results for the chronic study).