VITAMINS E/C & INCIDENT AD-BIRACIAL COMMUNITY STUDY

这项拟议的研究将评估总营养素摄入量 抗氧化剂维生素E和维生素C以及阿尔茨海默氏症 在8330名65岁及以上的两族人群中的疾病 生活在一个按地理位置划分的社区里东波士顿研究 提供的数据表明，维生素E和维生素C的使用可能与 降低患阿尔茨海默病的风险此外，本发明还提供了一种方法， 来自爱荷华州和东波士顿EPESE的初步数据似乎表明 使用维生素E可能导致认知障碍下降较少， 年龄爱荷华州和东波士顿以人口为基础的纵向设计 研究表明，结果不太可能是由于有偏见的估计; 然而，数据仅限于目前维生素补充剂的使用， 补充剂的使用者人数有限。拟定的研究将 提供总膳食摄入量的基线信息， 和过去使用维生素补充剂的参与者在芝加哥健康 老龄化项目拟议的研究将检验以下假设： (a)临床诊断的阿尔茨海默病的发病率较低， 维生素E摄入量较高的人。(b)临床发生率 在高摄入量的人中， 维生素C. (c)维生素E和维生素C的摄入量与 认知功能下降。此外，该研究将提供一个 说明特定老年人群体的营养摄入情况， 确定三年内营养素摄入量变化的预测因素， 并评估食物中营养素估计值的可靠性和有效性 频率问卷拟议的研究有三个组成部分： 1)营养摄入、认知功能和 其他协变量和芝加哥健康与老龄化研究中的流行疾病 项目，一项正在进行的基于人群的事件前瞻性研究 阿尔茨海默病，2）营养变化的随访评估 摄入量和认知功能，以及事件的临床评估 阿尔茨海默病三年基线，和3）进行 食物频率评定法的信度和效度研究 芝加哥健康与老龄化项目人群的营养摄入量。

The proposed study will assess the relation between total nutrient intake of the antioxidants, vitamin E and vitamin C, and incident Alzheimer's disease in a bi-racial population of 8330 persons 65 years and older living in a geographically-defined community. The East Boston studies provide data suggesting that use of vitamin E and vitamin C may be related to decreased risk of incident Alzheimer's disease. In addition, preliminary data from the Iowa and East Boston EPESE appear to indicate that vitamin E use may result in less decline in cognitive impairment with age. The population-based, longitudinal design of the Iowa and East Boston studies make it unlikely that the results are due to biased estimates; however, the data were restricted to current vitamin supplement use and there were a limited number of supplement users. The proposed study will provide baseline information on total dietary intake as well as current and past use of vitamin supplements for participants in the Chicago Health and Aging Project. The proposed study will test the following hypotheses: (a) Incidence of clinically diagnosed Alzheimer's disease is lower among persons with higher intake of vitamin E. (b) Incidence of clinically diagnosed Alzheimer's disease is lower among persons with higher intake of vitamin C. (c) Intakes of vitamin E and vitamin C are inversely related to decline in cognitive function. In addition, the study will provide a description of nutrient intake in a defined population of older persons, identify predictors of change in nutrient intake over a three-year period, and assess the reliability and validity of nutrient estimates from a food frequency questionnaire. There are three components to the proposed study: 1) the baseline assessment of nutrient intake, cognitive function and other covariates, and prevalent disease in the Chicago Health and Aging Project, an on-going population-based prospective study of incident Alzheimer's disease, 2) the follow-up assessment of changes in nutrient intake and cognitive function, and clinical evaluation of incident Alzheimer's disease three years from baseline, and 3) the conduct of reliability and validity studies on the food frequency method of assessing nutrient intake in the Chicago Health and Aging Project population.