MOTOR CONTROL IN CHRONIC FATIGUE SYNDROME

描述：(改编自《调查者摘要》) 使用电生理记录的授权期支持这一假设 CFS患者存在中枢运动控制障碍。此外， 其他人最近使用经颅磁刺激的研究也指出 CFS患者的中枢听觉通路异常。医院里的病人 我们的研究表明，在需要快速反应的任务中，反应时间变慢 以及伴随运动反应准备的大脑活动受损。 经颅磁刺激已经显示出过早的减少 CFS患者伴随持续运动活动的运动皮质输出。我们的 拟议的新项目的目标是定义更改的时间进程 慢性疲劳综合征运动诱导前后的运动皮质功能 疲惫。CFS异常的特异性将通过以下方法进行测试 并与一组临床抑郁症患者进行比较。这些方法 利用慢脑电位的神经生理学记录进行研究 伴随着几种不同类型的响应准备和 经颅磁刺激对运动皮质的影响程度 减少中央马达驱动。

DESCRIPTION: (Adapted from Investigator's Abstract) Results from the prior grant period using electrophysiological recordings support the hypothesis that patients with CFS have a disorder of central motor control. Moreover, recent studies by others using transcranial magnetic stimulation also point to the central auditory pathway as being abnormal in CFS. The patients in our studies showed slowed reaction times in tasks requiring rapid responses and impaired brain activities accompanying motor response preparation. Transcranial magnetic stimulation has demonstrated a premature reduction of motor cortical output in CFS accompanying sustained motor activities. Our goals in the proposed new project are to define the time course of altered motor cortical function in CFS before and after a period of exercise-induced fatigue. The specificity of the abnormalities for CFS will be tested by comparison with a group of patients with clinical depression. The methods of study utilize neurophysiological recordings of slow brain potentials accompanying several different types of response preparation and transcranial magnetic stimulation of motor cortex to measure the extent of reduction of central motor drive.