ENERGY METABOLISM IN REDUCED-OBESE SUBJECTS

这项为期两年的拟议项目旨在了解 与之相比，肥胖程度减轻的受试者能量代谢发生了改变 给从不肥胖的控制组受试者。该提案的一个主要假设 减肥者并不构成一个同质性的群体， 能量代谢可能会发生一些改变，但不是全部减少- 肥胖受试者。利用西北铁路，该项目将首先检查 减肥者静息代谢率的决定因素。 FORT-UP研究将检查总能量消耗(使用 双标记水)在保持短期(1-2)的受试者中 年)与长期(超过5年)的体重减轻。最后， 该项目将评估脂肪氧化对饮食的反应 减轻肥胖受试者的操控。以前没有研究过 肥胖受试者能量消耗减少曾使用受试者 与那些保持减肥超过5年的人在一起。 事实上，大多数以前减轻肥胖的受试者都是在 6个月的体重减轻。大幅减重可能会 在能量代谢中产生可能持续很长时间的扰动 一段时间。

The 2-yr proposed project is aimed at understanding whether or not energy metabolism is altered in reduced-obese subjects as compared to never-obese control subjects. A major hypothesis of the proposal is that the reduced-obese do not constitute a homogeneous group and that energy metabolism may be altered in some but not all reduced- obese subjects. Using the NWCR, the project will begin by examining determinants of resting metabolic rate in reduced-obese subjects. A foil ow-up study will examine total energy expenditure (using doubly labeled water) in subjects who have maintained short (1-2 year ) versus long (greater than 5 year) weight reduction. Finally, the project will assess fat oxidation in response to dietary manipulation in reduced-obese subjects. No previous studies of energy expenditure in reduced obese subjects have used subjects with who have maintained their weight loss for longer than 5 years. in fact, most previously reduced-obese subjects were studied within 6 months of their weight loss. Substantial weight loss can likely produce perturbation in energy metabolism that may last for long periods of time.