Regulation of mRNA translation by the microtubule-associated protein Tau

该项目旨在了解学习和记忆形成的细胞类型和亚细胞区室的分子过程。神经元的基本功能，如突触强化和记忆形成，都依赖于蛋白质翻译的严格调控过程。激酶Fyn（其定位于形成记忆的树突棘）激活ERK/S6通路，导致支架蛋白Tau的大量翻译。更重要的是，该级联的激活是Tau依赖性的。该项目旨在确定Tau如何激活这一通路，并破译Tau/Fyn/Tau反馈回路的生理作用。这将为我们了解学习和记忆的分子调节提供信息。

This project aims to understand the molecular processes in a cell type and subcellular compartment that underlies learning and memory formation. Fundamental neuronal functions such as synaptic strengthening and memory formation are dependent on the tightly regulated process of protein translation. The kinase Fyn (which is localised to dendritic spines where memories are formed) activates the ERK/S6 pathway leading to massive translation of the scaffolding protein Tau. More importantly, the activation of this cascade is Tau-dependent. This project aims to determine how Tau activates this pathway, and to decipher the physiological role of the Tau/Fyn/Tau feedback loop. This will inform our understanding of the molecular regulation of learning and memory.