Mimicking the perivascular niche with boronolectin-based biomaterials

该项目旨在通过发现新的机制和材料来改善延长培养过程中细胞质量的结果，从而解决血管周围干细胞制造中的障碍。一种创新的跨学科生物材料发现方法，结合基于活细胞的细胞表面多聚糖筛选、生物启发的材料设计和合成以及利基模拟，将能够发现支持长期扩张和效力维持的细胞表面多糖介导的相互作用，以及能够模拟它们的合成生物材料。该项目和这一可扩展生物材料平台的应用有望为干细胞研究人员、制造商和最终用户带来重大好处。

This project aims to address roadblocks in perivascular stem cell manufacturing by discovering novel mechanisms and materials that improve cell quality outcomes during extended culture. An innovative, interdisciplinary approach to biomaterials discovery, combining live cell-based screening of cell surface glycans, bio-inspired materials design and synthesis, and niche mimicry, will enable the discovery of cell surface glycan-mediated interactions that support long-term expansion and potency maintenance, and synthetic biomaterials that can mimic them. Significant benefits for stem cell researchers, manufacturers and end users are expected from the project and the application of this scalable biomaterial platform.