VESTIBULAR AFFERENT ACTIVITY AFTER CANAL PLUGGING

产品说明： 堵塞的互惠半规管对消除了反应 以0.2的频率绕其相关轴旋转 Hz.在更高的频率下，存在空间的异常化。 角前庭眼反射（aVOR）。 的假设 这项研究表明，这种正常化的发生是因为堵塞不 消除堵塞根管的反应。 相反，它改变了运河 动力学，从而降低渠道的主导时间常数。 在 目前，没有直接证据表明堵塞的运河传入响应于 旋转频率更高。 也没有中枢前庭活动 在运河堵塞后进行了研究，以确定是否确实存在 空间适应 目的工作将解决以下问题： 运河堵塞是否改变了 对旋转的反应？ 如何将空间特征的 中央前庭神经元受到侧管堵塞的影响， 侧管神经的切片 前庭传入神经 食蟹猴将在双侧侧管之前和之后记录 堵塞 预计侧半规管的调制幅度 在插入后，传入在0.2 Hz处将近似为零，但将倾向于 当头部振荡频率增加到4.0 Hz时， 垂直神经管传入神经应保持其正常频率 特色 空间眼神经元和前庭中枢神经元 将在双侧神经切片后比较反应， 运河堵塞后，确定是否有显着的空间 神经切断后的适应 预计空间响应 会因为中枢适应而改变，但空间上的变化 作为频率函数的响应将不像运河那样显著 堵塞 这项工作应该导致更清楚地了解病变， 如堵塞、神经切断等，影响头部感觉加工 运动以及中央前庭系统如何适应这些类型的 病变

DESCRIPTION: Plugging of reciprocal semicircular canal pairs eliminates the response associated with rotation about their associated axis at a frequency of 0.2 Hz. At higher frequencies, there is a Anormalization of the spatial responses of the angular vestibulo-ocular reflex (aVOR). The hypothesis of this study is that this normalization occurs because plugging does not eliminate the respons of the plugged canal. Rather, it modifies the canal dynamics so that the dominant time constant of the canal is lowered. At present, there is no direct evidence that plugged canal afferents respond to rotation at higher frequencies. Neither has central vestibular activity been studied following canal plugging to determine if indeed there is spatial adaptation. The purpose work will address the following questions: Does canal plugging modify the spatial and temporal characteristics of the afferents in response to rotation? How will the spatial characteristics of central vestibular neurons be affected by plugging of the lateral canals and by section of the lateral canal nerves? Vestibular afferents of the cynomolgus monkeys will be recorded before and after bilateral lateral canal plugging. It is expected that the amplitude of modulation of lateral-canal afferents will be approximately zero at 0.2 Hz after plugging, but will tend to Anormalize as the head oscillation frequency is increased up to 4.0 Hz. Vertical canal afferents should maintain their normal frequency characteristics. Spatial oculomotor and central vestibular neuronal responses will be compared following bilateral sectioning of the nerves and after canal plugging to determine whether there is significant spatial adaptation following nerve cut. It is expected that the spatial responses will be altered due to central adaptation, but that changes in spatial responses as a function of frequency will not be as significant as for canal plugging. This work should lead to a clearer understanding of how lesions, such as plugging and nerve section, affect the sensory processing of head movements and how the central vestibular system adapts to these types of lesions.