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IDENTIFICATION OF HIV-1 MODULATED GENES

IDENTIFICATION OF HIV-1 MODULATED GENES
HIV-1 调节基因的鉴定
批准号：
2463648
负责人：
J A LAUTENBERGER
金额：
$0.0万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/2463648
关键词：
HIV infections gene expression genetic library host organism interaction human immunodeficiency virus 1 human tissue macrophage northern blottings tissue /cell culture virulence virus RNA virus genetics

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中文摘要
翻译
HIV-1诱导的疾病涉及病毒和病毒之间复杂的相互作用 寄主因素。为了更好地了解宿主对病毒的反应 感染，使用差异显示技术来识别 在HIV-1感染和感染之间差异表达的基因 -未感染的巨噬细胞。对于几个基因，差异表达 经RNA凝胶印迹(Northern)分析证实。这项研究显示 在感染细胞中高水平表达的这两个基因，如 以及在感染细胞中表达水平较高的那些基因。 其中有几个基因的表达非常有限或无法检测到 在未感染的组织中。
英文摘要
HIV-1-induced disease involves the complex interactions of viral and host factors. To better understand the host response to viral infection, the differential display technique was used to identify genes that are differentially expressed between HIV-1-infected and -uninfected macrophages. For several genes, differential expression was confirmed by RNA gel blot (Northern) analysis. The study revealed both genes that are expressed at higher levels in infected cells, as well as ones that are expressed at higher levels in infected cells. Several of these genes had very restricted or undetectable expression in uninfected tissues.
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会议论文
ANALYSIS OF HIV MESSENGER RNA STRUCTURE
IDENTIFICATION OF MOLECULAR MARKERS FOR HUMAN LUNG CANCER
ANTISENSE OLIGONUCLEOTIDES AS INHIBITORS OF TUMOR-INDUCED ANGIOGENESIS
STRUCTURAL, BIOCHEMICAL, AND BIOLOGICAL CHARACTERIZATION OF HIV NEF AND VPU
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