STUDIES OF PHENOLPHTHALEIN CONTAINING LAXATIVE USE AND NEOPLASIA

酚酞，许多泻药中的一种成分，显示出明显的证据。 最近对啮齿动物的两年喂养研究中的致癌活性 由国家毒理学计划(NTP)完成。约3%的 美国老年人口使用含酚酞的泻药治疗 按天算。我们将研究酚酞与- 含有泻药的使用有患卵巢癌和腺瘤的风险 人类的大肠息肉。 我们已经与委托人建立了合作协议 正在进行的两项病例对照危险因素研究的调查人员 卵巢癌。在我们的怂恿下，这些调查人员插入了 在他们的调查问卷中添加了两页的内容，以确定使用 特定的含酚酞的泻药。每项研究都会得出 大约300个病例和300个对照，数据将准备好进行分析 在1999年。 艾滋病危险因素的两项病例对照研究资料收集 腺瘤性结直肠息肉已经完成。关于泻药使用的数据 都可用于这两项研究。我们将检查泻药的用法与 在这些数据中有息肉的风险。息肉与使用药物的关系 所有的泻药和含有酚酞的泻药都会 在考虑到饮食和其他风险因素后进行探索 结直肠腺瘤。

Phenolphthalein, a constituent in many laxatives, showed clear evidence of carcinogenic activity in 2-year feeding studies in rodents recently completed by the National Toxicology Program (NTP). About 3% of the older U.S. population uses phenolphthalein-containing laxatives on a daily basis. We will investigate the relation of phenolphthalein- containing laxative use with risk of ovarian cancer and adenomatous colorectal polyps in humans. We have established collaborative agreements with the principal investigators for two ongoing case-control studies of risk factors for ovarian cancer. At our instigation, these investigators have inserted into their questionnaire a 2-page addition that ascertains use of specific phenolphthalein-containing laxatives. Each study will yield about 300 cases and 300 controls, and the data will be ready for analysis in 1999. Data collection for two case-control studies of risk factors for adenomatous colorectal polyps have been completed. Data on laxative use are available for both studies. We will examine laxative use in relation to risk of polyps in these data. The association of polyps with use of all laxatives and phenolphthalein-containing laxatives specifically will be explored after taking into account dietary and other risk factors for colorectal adenomas.