NEW SCINTIGRAPHY MAMMOGRAPHY CAMERA

拟议工作的目标是进行可行性研究。 导致了一种新的、新的闪烁成像探测器的开发 乳房X光摄影可提高对乳腺癌的诊断和 降低假阳性诊断的数量，从而导致不必要的 侵入性活检，从而减少了患者在治疗期间的创伤 同时节省数十亿美元的国家医疗账单， 现在与这些程序有关。这个概念是基于伽马- 射线探测器，它结合了CsI(Tl)闪烁体阵列，耦合到新的 硅PIN二极管光电探测器阵列和大规模键合的铟凸点 低噪声集成读出芯片，形成高能量分辨率和 高空间分辨率成像探测器。建议的发展项目将会 引线(在第二阶段)通向紧凑型设备，该设备将包括高 分辨率准直器、CsI(Tl)闪烁体和PIN光电二极管阵列 紧密耦合到高密度、低噪音的电子设备。这个 发展将经历两个截然不同的阶段。在第一阶段，我们将 4×4(16像素)硅PIN二极管原型的设计与制作 列出并调查以下所需的技术要求 制作和组装闪烁体，并用于集成 闪烁体与光电二极管阵列。我们将使该阵列与 已有的包含低噪声的16通道读出芯片 前置放大器和放大器。我们将评估 原型结构，并与记录结果(7.5%半高宽)进行比较 能量分辨率)在2x2x4 mm CSI(Tl)的初步研究中获得 闪烁体与2x2 mm PIN光电二极管耦合。在第二阶段，我们将 开发至少625像素的放大和优化设备 单个约5厘米乘以5厘米的芯片，并开发集成技术 所有的前端组件。我们还将开发具体的新产品 具有625个全通道优化低噪声的读出电子设备 所需的前置放大器、优化放大器和逻辑电路 在单个芯片上将信号多路复用到MCA。我们还将 调查设备的包装和马赛克要求 这些器件结合在一起，形成更大的焦平面阵列。 建议的商业应用：在第三阶段，我们将开发 基于第一阶段和第二阶段努力的商用探测器系统。 这些新的探测器可能导致新一代临床成像 用于改进乳房X光照相的设备。应用程序之外的联合 通过乳房X光检查，正在开发的设备是许多 更大的相机，空间和光谱性能比任何其他相机都好 今天正在使用的相机，而且成本更低。有一个非常大的市场 这项技术是由对改进的诊断工具的需求推动的 用于核医学。

The objective of the proposed work is to perform feasibility studies leading to the development of a novel, new detector for scintigraphy mammography capable of improving the diagnosis of breast cancer and lowering the number of false-positive diagnoses leading to unnecessary invasive biopsies, thereby reducing trauma to the patient while at the same time saving billions of dollars in the national medical bill that are now associated with these procedures. The concept is based upon a gamma- ray detector which combines a CsI(Tl) scintillator array coupled to a new Si-PIN diode photodetector array and indium-bump bonded to a large-scale low-noise integrated readout chip to form a high energy-resolution and high spatial-resolution imaging detector. The proposed development will lead (in Phase II) to a compact device which will include a high resolution collimator, CsI(Tl) scintillator and PIN photodiode array intimately coupled to the high-density low-noise electronics. The development will proceed through two distinct phases. In phase I we will design and fabricate a prototypical four-by-four (16-pixel) Si-PIN diode array and investigate the technological requirements necessary for fabricating and assembling the scintillator and for integration of the scintillator with the photodiode array. We will interface the array with an already existing 16-channel readout chip containing low-noise preamplifiers and amplifiers. We will evaluate the performance of the prototypical structure and compare it with the record results (7.5% FWHM energy resolution) obtained in preliminary studies on a 2x2x4mm CsI(Tl) scintillator coupled with a 2x2mm PIN photodiode. In phase II we will develop a scaled-up and optimized device with at least 625-pixels on a single ca. 5 cm by 5 cm chip and develop the technology for integrating all of the front-end components. We will also develop specific new readout electronics with 625 full channels of the optimized low-noise preamplifier, optimized amplifier, and logic circuits required for multiplexing the signals to the MCA on a single chip. We will also investigate packaging of the device and requirements for mosaicing the devices together to form larger focal plane arrays. PROPOSED COMMERCIAL APPLICATION: In the THIRD phase we will develop commercial detector systems based upon the Phase 1 and Phase 2 efforts. These new detectors could lead to a new generation of clinical imaging devices for improved mammography. Beyond the application in conjunction with mammography, the device under development is a precursor to much larger cameras with better spatial and spectral performance than any other camera in use today, and at lower cost. There is a very large market for this technology which is driven by the need for improved diagnostic tools for nuclear medicine.