COGNITIVE ABILITIES OF AT RISK ELDERLY FOR DEMENTIA

拟议的研究将回顾研究家庭成员的角色 老年老年性痴呆患者神经心理能力的风险 进展性痴呆阳性家族史(FHPD+)。FHPD+ 受试者将从现有的非痴呆症队列中招募 来自国家阿尔茨海默病研究中心的老年受试者 (ADRC)加州大学圣地亚哥分校(UCSD) 医学上，神经心理能力的回顾分析将是 对从这些人那里收集的行为数据进行分析。FHPD+ 受试者将通过获得的病史/家族史访谈来确定 由ADRC提供，并将进行分组匹配并与非痴呆症进行比较 来自ADRC的老年人，尚未确定其家族史 痴呆症(FH)。此外，另一批正常老年人 将从社区招募个人，以供未来使用 分析。这些受试者将被确认为一级亲属 尸检确认的AD患者中接受过 ADRC的神经病理学核心(即，有阳性家族的受试者 明确的阿尔茨海默病病史；FHAD+)。这些时尚的受试者 将被招募，以努力采用更严格的方法 识别家族性风险。以及从 通常给予ADRC受试者的神经心理电池，一种新的 一组持续的临床和实验神经心理学测试 以及注意力分散，以及旨在量化策略使用的测试 在解决问题和记忆方面，并将得到管理。建议数 研究将扩大我们对神经心理特征的了解 非常早期的DAT，有助于确定临床前认知 标记存在于某些遗传易感个体中，有可能患上 阿尔茨海默病的发展。

The proposed studies will retrospectively examine the role of familial risk in the neuropsychological abilities of elderly individuals with a positive family history for progressive dementia (FHPD+). The FHPD+ subjects will be recruited from the existing cohort of nondemented elderly subjects from the National Alzheimer's Disease Research Center (ADRC) of the University of California, San Diego (UCSD), School of Medicine, Retrospective analyses of neuropsychological abilities will be performed on behavioral data gathered from these individuals. FHPD+ subjects will be identified by medical/family history interviews obtained by the ADRC, and will be group-matched and compared to nondemented elderly from the ADRC who have not identified a family history for dementia (FH). Furthermore, an additional cohort of normal elderly individuals will be recruited from the community for prospective analyses. These subjects will be identified as first-degree relatives of autopsy-confirmed AD patients who have been examined by the Neuropathology Core of the ADRC (i.e., subjects with a positive family history for "definite" Alzheimer's disease; FHAD+). These FHAD+ subjects will be recruited in an effort to employ more rigorous methods in identifying familial risk. Along with tests selected from the neuropsychological battery normally given to ADRC subjects, a novel battery of clinical and experimental neuropsychologic tests of sustained and divided attention, as well as tests designed to quantify strategy use in problem-solving and memory, and will be administered. The proposed studies will extend our knowledge of the neuropsychologic characteristics of very early DAT, and help to determine whether preclinical cognitive markers exist in certain genetically susceptible individuals at risk for the development of Alzheimer's disease.