CELL AND MOLECULAR BIOLOGY OF DENDRITIC CELLS

描述：此应用程序请求Keystone的部分支持 树突状细胞的细胞和分子生物学研讨会。 专门 树突状细胞（DC）是免疫应答过程中重要的抗原提呈细胞， 产生免疫力和耐受力。 的分子机制 树突状细胞的功能现在更容易获得，主要是因为 方法来产生树突状细胞在更大的数量和在不同的 功能状态。 会议将讨论几个新兴领域 树突状细胞生物学，并接口这些领域与B和T淋巴细胞 功能，特别是在淋巴器官原位。 主题包括（1） DC发育的不同骨髓和淋巴途径的证据，（2） TNF受体家族在控制DC功能中的关键作用，（3） DC生物学和DC限制性产物的分子遗传学方法，（4） 抗原加工途径，（5）趋化因子的产生和趋化因子 受体，（6）DC和T细胞之间的通讯，以及不同的 DC和B细胞的类型，（7）病毒与DC的相互作用，（8）DC 和Th 1/Th 2分化的控制，（9）粘膜表面的DC，和 (10)中枢和外周耐受的DC。 正确连接DC 对于淋巴细胞功能，几位受邀演讲者将是以下方面的专家 免疫生物学的新兴领域。 会议组织者是拉尔夫·斯坦曼，教授在实验室的 洛克菲勒大学细胞生理学和免疫学 Nussenzweig，分子免疫学实验室教授， 洛克菲勒大学;和雅克·班什罗，贝勒大学校长 免疫学研究所。

DESCRIPTION: This application requests partial support of the Keystone Symposium on Cell and Molecular Biology of Dendritic Cells. Specialized dendritic cells (DC) are important antigen presenting cells during the generation of immunity and tolerance. The molecular and cellular mechanisms of dendritic cell function are now more accessible, primarily because of methods to generate dendritic cells in larger numbers and in different functional states. The conference will address several emerging new areas of dendritic cell biology, and interface these areas with B and T lymphocyte functions, particularly in situ in lymphoid organs. Topics will include (1) evidence for distinct myeloid and lymphoid pathways of DC development, (2) the key role of the TNF-receptor family in the control of DC function, (3) molecular genetic approaches to DC biology and DC-restricted products, (4) antigen processing pathways, (5) chemokine production and chemokine receptors, (6) communications between DCs and T cells, and between different types of DCs and B cells, (7) the interactions of viruses with DCs, (8) DCs and the control of Th1/Th2 differentiation, (9) DCs at mucosal surfaces, and (10) DCs in central and peripheral tolerance. To properly interface DCs with lymphocyte function, several of the invited speakers will be experts in emerging areas of immunobiology. The conference organizers are Ralph Steinman, Professor in the Laboratory of Cellular Physiology and Immunology at Rockefeller University; Michel Nussenzweig, Professor in the Laboratory of Molecular Immunology at Rockefeller University; and Jacques Banchereau, Director of the Baylor Institute for Immunology Research.