CONFERENCE ON THE ENTERIC NERVOUS SYSTEM

肠道神经系统(Ens)是最大和最复杂的区域 美国国家安全局。它是唯一可以调节反射的外周区域 在没有中枢神经系统投入的情况下的活动。因此，ENS是一种 被比作第二个大脑的独立神经实体。 事实上，它的结构和神经化学成分与 大脑。尽管它的神经生物学的复杂性，这是众所周知的 近一个世纪以来，ENS刚刚走出一段漫长的 科学上的忽视。它的重新发现引起了人们的兴奋，不仅是 在科学界，也在医生中，他们 被功能性疾病患者的无法治愈的问题所淹没 肠道综合征。ENS也成为#年研究的主要焦点。 发育神经生物学，部分原因是已经取得了很大的进展 了解肠神经发育中的基因表达，以及 部分原因是先天性鼻咽癌的发病机制可以 现在大家都明白了。因此，拟议的对外经济司会议的重点是 时机恰到好处，几乎是独一无二的。新信息的获取是 呈指数级增长。在将形态学家聚集在一起的过程中， 生理学家、分子生物学家、发育生物学家， 免疫学家、药理学家和临床医生，会议将采取 第一次获得了学科一致性的优势 这一点ENS变得很重要。会议将以以下形式开始 单个肠神经细胞鉴定的最新进展和 负责内在肠道感觉、整合、 和反射活动。同样要考虑的还有建筑群 大脑和肠道之间的相互作用，生理和 肠道神经递质及其受体的药理学，包括 NO所起的争议性作用及其功能、发展和 肠内起搏器Cajal间质细胞的神经支配。 相当长的时间将用于基因和神经元的发育。 以及这些基因的突变所起的作用(S)。 疾病的发病机制。 最后，基础-临床会议将尝试将新的 将儿科知识扩展到临床医生所面临的问题 当肠道出现故障时，必须进行治疗。正式会议将是 并辅之以海报和非正式讲习班。一项重大努力将是 目的是吸引年轻的调查人员参加会议，并让他们 与可以担任顾问和角色的资深科学家互动 模特们。

The enteric nervous system (ENS) is the largest and most complex region of the PNS. It is the only peripheral region that can mediate reflex activity in the absence of input from the CNS. The ENS is thus an independent neural entity that has been likened to a second brain. Indeed, its structure and neurochemical content resemble those of the brain. Despite its neurobiological sophistication, which has been known for almost a century, the ENS is just emerging from a long period of scientific neglect. Its rediscovery has generated excitement, not only in the scientific community, but also among medical practitioners, who are swamped by the untreatable problems of patients with the functional bowel syndrome. The ENS has also become a major focus of research in developmental neurobiology, in part because great progress has been made in understanding gene expression in enteric neuronal development, and in part because the pathogenesis of congenital defects of the ENS can now be understood. The proposed Keystone Conference on the ENS is thus well timed and almost unique. The acquisition of new information is rising exponentially. In bringing together morphologists, physiologists, molecular biologists, developmental biologists, immunologists, pharmacologists, and clinicians, the conference will take advantage, for the first time, of the congruence of disciplines for which the ENS has become important. The conference will begin with recent progress in identifying individual enteric neurons and the microcircuits responsible for intrinsic enteric sensation, integration, and reflex activity. Also to be considered will be the complex interactions between the brain and the gut, the physiology and pharmacology of enteric neurotransmitters and their receptors, including the controversial role played by NO, and the function, development, and innervation of the enteric pacemaker, the Interstitial Cell of Cajal. Considerable time will be devoted to the genes and neuronal development as well as to the role(s) played by mutations of these genes in the pathogenesis of disease. Finally, basic-clinical sessions will attempt to related the newly expanded knowledge of the ENS to the problems faced by clinicians who must treat the bowel when it malfunctions. Formal sessions will be supplemented by posters and informal workshops. A major effort will be made to attract young investigators to the meeting and to get them to interact with senior scientists who can serve as advisors and role models.