BREAST CANCER RISK FACTORS IN HISPANIC WOMEN

尽管加利福尼亚州的西班牙裔女性乳房发病率低50% 癌症比非西班牙裔白人女性多，乳腺癌是首位 西班牙裔妇女罹患癌症的事件。到目前为止，还没有发布关于 美国拉美裔美国人患乳腺癌的风险因素是可用的，但没有分析 研究探索了发病率差异的原因 在西班牙裔白人和非西班牙裔白人之间。我们建议进行一项 旧金山湾区人群病例对照研究 认为自己是西班牙裔白人的女性，并评估 乳腺癌与移民模式和文化适应的关系， 以及潜在的可改变的因素，如体力活动、维生素 D来自日光照射和饮食，以及母乳喂养，这些都有 目前可获得的流行病学数据有限或不一致。西语裔 年龄在3岁到79岁之间的新诊断乳腺癌的白人女性将 通过两个以人群为基础的癌症登记来确定。案件将会 包括1995年至2005年期间所有被诊断患有乳腺癌的西班牙裔妇女 1998年。西班牙裔白人控制将通过随机数字标识 按五岁年龄组按比例拨号和频率匹配的病例 每个病例有1.5个对照。训练有素的双语和双文化面试者 将执行结构化问卷调查并测量皮肤色素沉着 用于估计病例和802个对照。在家庭访谈中 将收集关于移民模式、文化适应、 体力活动，来自阳光暴晒和饮食的维生素D，乳房 喂养，并确定了乳腺癌的危险因素，如生殖 和体型特征。病例和对照将与 关于这些暴露变量的非条件Logistic回归分析 将被用来估计乳腺癌的优势比 这些风险因素，控制了年龄和潜在的混杂 变量。我们还将比较风险因素的流行率和 不同移民模式的拉美裔美国人的关联度 和文化适应的程度。在可能的范围内，我们将评估 风险因素的差异在多大程度上解释 西班牙裔白人和非西班牙裔白人女性之间的发病率。

Although Hispanic women in California have 50% lower incidence of breast cancer than non-Hispanic white women, breast cancer is the leading incident cancer in Hispanic women. Yet to date, no published data on breast cancer risk factors in US Hispanics are available, and no analytic study has explored the reasons for the differences in incidence rates between Hispanic whites and non-Hispanic whites. We propose to conduct a population-based case-control study in the San Francisco Bay area among women who identify themselves as Hispanic white, and to assess the associations of breast cancer with migration patterns and acculturation, and with potentially modifiable factors such as physical activity, vitamin D from sunlight exposure and diet, and breast-feeding, for which there are at present limited or inconsistent epidemiologic data available. Hispanic white women aged 3 to 79 years with newly diagnosed breast cancer will be ascertained through two population-based cancer registries. Cases will include all Hispanic women diagnosed with breast cancer between 1995 and 1998. Hispanic white controls will be identified through random-digit dialing and frequency-matched to cases by five-year age group in a ratio of 1.5 controls per case. Trained bilingual and bicultural interviewers will administer a structured questionnaire and measure skin pigmentation for an estimated 535 cases and 802 controls. In home interviews information will be collected on migration patterns, acculturation, physical activity, vitamin D from sunlight exposure and diet, breast feeding, and established breast cancer risk factors such as reproductive and body size characteristics. Cases and controls will be compared with regard to these exposure variables, and unconditional logistic regression will be used to estimate the odds ratios for breast cancer associated with these risk factors, controlling for age and potentially confounding variables. We will also compare the prevalence of risk factors and magnitudes of associations in Hispanics with different migration patterns and levels of acculturation. To the extent possible, we will evaluate the degree to which differences in risk factors explain the difference in incidence rates between Hispanic white and non-Hispanic white women.