A link between antibiotic resistance and bacterial sporulation
A link between antibiotic resistance and bacterial sporulation
批准号:
DP190102969
负责人:
Prof Dena Lyras
金额:
$30.95万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2019
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2019-01-01 至 2021-12-31
中文摘要
本项目旨在定义艰难梭菌的产孢过程,并推进我们对抗生素使用与产孢之间联系的理解。为了在恶劣的环境中生存,一些细菌产生一种休眠的、有弹性的细胞形式,称为孢子,它可以在不利的环境中存活多年,但我们对这一过程如何发生的理解有限。该项目将对孢子形成过程和抗生素使用的长期有害影响提供更深入的了解。该项目预计将提供经济效益,减少环境微生物污染,并有助于改善动物和人类的健康。
英文摘要
This project aims to define the sporulation process in the bacterium Clostridium difficile, and advance our understanding of a link between antibiotic use and sporulation. To survive in hostile environments, some bacteria produce a dormant and resilient cell form called a spore which can survive for many years in unfavourable environments, but our understanding of how this process occurs is limited. This project will provide a deeper understanding of the sporulation process and the long-lasting detrimental impact of antibiotic use. The project expects to provide economic benefits, reduce environmental microbial contamination and contribute to better health of animals and humans.
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