Lifespan-dependent molecular shaping of the T cell receptor repertoire

哺乳动物有一个错综复杂的免疫系统，其功能在一生中不断变化。然而，为什么以及如何发生这种情况是非常不清楚的，但仍然是一个关键问题。该项目旨在提供有关人类寿命如何塑造特定T细胞受体的基础知识，并确定在生命的免疫学不同阶段获得功能和丧失功能的分子机制。该项目将提供多维，高通量数据集的分析，以确定转录景观和TCR签名之间的基本联系，从而将显着回答该领域的关键免疫学问题。

Mammals have an intricate and highly complex immune system, whose function alters throughout life. Why and how this occurs is very unclear however, yet remains a crucial question. This project aims to provide fundamental knowledge on how the human lifespan shapes specific T cell receptors and determine molecular mechanisms underlying gain-of-function and loss-of-function during immunologically distinct phases of life. This project will provide analysis of multi-dimensional, high throughput datasets to identify fundamental links between the transcriptional landscape and TCR signatures across human lifespan, thus will significantly answer key immunological questions in the field.