Molecular study of copper-promoted ubiquitination

本项目旨在研究铜促进的泛素化，这是一个新的发现，在结合酶UBE2D2中保守的铜结合位点促进包括肿瘤抑制基因p53在内的一系列蛋白质的泛素化。它预测了铜稳态和细胞蛋白稳态之间的相关性，并可能使阿尔茨海默病和癌症之间的反向关系合理化。该项目将采用一系列综合方法来阐明这种铜作用的分子性质。预期的结果包括对这一过程的分子机制的理解，以及加强跨学科合作。潜在的好处包括干预铜相关疾病的新策略。

This project aims to study copper-promoted ubiquitination, a novel discovery that a conserved copper binding site in conjugating enzyme UBE2D2 promotes ubiquitination of a range of proteins including tumor suppressor p53. It predicts a correlation between copper homeostasis and cellular proteostasis and may rationalise an inverse relationship between Alzheimer's disease and cancer. This project will employ a range of integrated approaches to illuminate the molecular nature of this copper action. Expected outcomes include an understanding of the molecular mechanisms of this process, and enhanced interdisciplinary collaboration. Potential benefits include new strategies to intervene in copper-related disorders.