CRYO ROP PARTICIPATING CENTER--PHASE III

第三阶段的具体目标： 冷冻ROP随机化部分随访的具体目标 研究的目的是解决以下问题： 眼部有长期的结构性或功能性后遗症吗？ 使用冷冻疗法治疗的阈值ROP(与那些 不治疗)，这将需要重新评估风险/收益比率 推荐冷冻疗法吗？ 2.研究数据是否表明冷冻治疗的“门槛”应该是 被放低了？ 在7岁、8岁、9岁和10岁时进行年度眼睛检查。 在随机分组的ROP患者中。 低温ROP的自然历史部分的具体目标如下- UP研究仅涉及那些未发生ROP AS的冷冻性ROP儿童 一个婴儿。检查将在7岁、9岁和10岁进行 在这些研究中，患者和数据收集旨在解决 与随机化的第三阶段研究相同的眼部状况问题 病人。

Phase III Specific Aims: The specific aims of the randomized portion of the CRYO-ROP follow-up study are to address the following questions: I. Are there long-term structural or functional ocular sequelae in eyes with Threshold ROP that are treated with cryotherapy (vs. those that are not treated) that would require re-evaluation of the risk/benefit ratio of recommending cryotherapy? 2. Do the study data suggest that the "threshold" for cryotherapy should be lowered? Yearly eye examinations will be performed at 7, 8, 9, and 10 years of age in the randomized ROP patients. The specific aims of the Natural History portion of the CRYO-ROP follow- up study involve only those CRYO-ROP children who did not develop ROP as an infant. Examinations will be performed at 7, 9, and 10 years of age in these study patients and data collection is designed to address the same ocular status question as the Phase III study of randomized patients.