CENTRAL CHOLINERGIC PATHWAYS

描述：在摘要陈述中，首席调查员是 批评：(1)缺乏一个相互联系的中心假说 三个具体目标；(2)没有任何明显的决策树 指导拟议的研究；以及(3)缺乏初步数据 记录开展多项建议的可行性 学习。作为对这些具体批评的回应，应用程序具有 进行了相当大的修订，因此得到了改进。其中 这些修订取消了所有关于抗体的研究 对抗M_1、M_3、M_4和M_5受体及所有EM 死后的人类样本。此外，具体的假设和 指导所提议的实验的决策树更加精细 呈上了。为此，首席调查员编写了一份概览 该图概括了胆碱能通路的两个已知成分 在灵长类动物的大脑皮层和那些将 将由本提案予以解决。

DESCRIPTION: In the summary statement the principal investigator was criticized: (1) for the lack of a central hypothesis linking together the three specific aims; (2) the absence of any obvious decision tree guiding the proposed studies; and (3) the lack of preliminary data documenting the feasibility of conducting a number of the proposed studies. In response to these specific criticisms the application has been considerably revised and as a result has been improved. Among these revisions is the elimination of all studies with antibodies against the muscarinic receptors m1, m3, m4 and m5 and all EM work on post-mortem human specimens. In addition, the specific hypotheses and decision trees guiding the proposed experiments are more elaborately presented. To this end the principal investigator prepared an overview figure summarizing both the known components of the cholinergic pathways in the primate cerebral cortex and those unknown components that will be addressed by the present proposal.