GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS

描述：冠心病仍然是导致心脏病的主要原因之一 美国血脂浓度的发病率和死亡率很高 疾病程度的预测指标。要优化的饮食建议 血脂谱包括总膳食脂肪、饱和脂肪的减少 和胆固醇。然而，个体对饮食的反应表明， 是血清脂蛋白对饮食反应的强烈遗传成分 操纵。私家侦探和他的研究团队以及其他人 研究人员已经表明，几个候选基因的多态 与脂肪代谢有关的是与饮食反应增加相关的 干预性研究。这些候选基因包括apoA-I、apoB、apoE 以及apoC-III和apoA-IV。这项提案的目标是：1)确定 6个候选基因座9个遗传变异对空腹血糖的影响 血浆总胆固醇、低密度脂蛋白、高密度脂蛋白和甘油三酯 活人口(Framingham后代，n=3,600和Omni，n=1,200 非裔美国人和西班牙裔美国人)以及饮食对他们的影响 习惯、年龄、性别和其他环境变量；以及2)决定 这些基因座的遗传变异对个体血脂的影响 在自由生活中改变饮食习惯带来的变化 人口。

DESCRIPTION: Coronary heart disease remains one of the primary causes of morbidity and mortality in the U.S. Plasma lipid concentrations are strong predictors of the extent of disease. Dietary recommendations to optimize plasma lipid profiles include reductions of total dietary fat, saturated fat and cholesterol. However, individual responses to diet suggest that there is a strong genetic component to serum lipoprotein response to dietary manipulation. The P.I. and his research team, as well as other investigators, have shown that polymorphisms in several candidate genes related to lipid metabolism are associated with increased dietary response to intervention studies. These candidate genes include apoA-I, apoB, apoE and apoC-III and apoA-IV. The goals of this proposal are to: 1) determine the effects of nine genetic variants at six candidate gene loci on fasting plasma total, LDL, HDL-cholesterol and triglyceride concentrations in a free living population (Framingham Offspring, n=3,600 and OMNI, n=1,200 African-American and Hispanic Cohorts) and their modulation by dietary habits, age, gender and other environmental variables; and 2) determine the effect of genetic variability at these loci on individual plasma lipid changes resulting from modification of dietary habits in a free living population.