New Protocols for the Chemical Synthesis of Biologically Relevant Systems

将开发和利用酶和金属催化工艺，以建立生物活性和其他难以获得的天然产物及其类似物的简明合成。目标结构的范围在结构上是多种多样的，这些结构有可能作为农用化学品和/或治疗剂，用于治疗哺乳动物的一系列疾病状态，包括细菌和病毒感染、神经退行性疾病和认知功能受损。抗血管生成化合物控制不受调节的细胞生长也可能来自这些研究。用于化学酶合成的新一代同手性代谢物也应该从这个项目中出现。

Enzyme- and metal-catalysed processes will be developed and exploited for the purpose of establishing concise syntheses of biologically active and otherwise inaccessible natural products and their analogues. The range of structures to be targeted is structurally diverse and these have the potential to act as agrochemicals and/or as therapeutic agents for the treatment of a range of disease states in mammals including bacterial and viral infections, neuro-degenerative conditions and impaired cognitive function. Anti-angiogenic compounds that control otherwise unregulated cellular growth may also arise from these studies. The generation of new, homochiral metabolites for use in chemoenzymatic synthesis should also emerge from this project.