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STRUCTURE/FUNCTION DYNAMICS OF NGF RECEPTORS

STRUCTURE/FUNCTION DYNAMICS OF NGF RECEPTORS
NGF 受体的结构/功能动力学
批准号：
2614537
负责人：
David E. Wolf
金额：
$25.48万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
项目状态：
已结题
起止时间：
1993-08-01 至 2002-03-31
来源：
https://reporter.nih.gov/project-details/2614537
关键词：
PC12 cells biological signal transduction biophysics confocal scanning microscopy conformation dimer fluorescence microscopy fluorescence spectrometry glycoproteins growth factor receptors image processing immunofluorescence technique membrane activity neurotrophic factors photochemistry protein engineering protein structure function protein tyrosine kinase radiofluorescent probe receptor binding receptor expression recombinant proteins stoichiometry

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中文摘要
翻译
描述（改编自申请人摘要）：神经生长因子（NGF） 是一种蛋白质的发展，维护和修复所需的 神经系统 有两种NGF受体，gp75和酪氨酸激酶 TrkA。 这两种受体都可以单独发出信号， 相互激活多种信号转导途径。 的 研究人员假设，神经生长因子诱导的受体二聚化， 这些研究可能为以下方面提供物理基础： 神经生长因子受体信号，从而帮助开发新的方法 用于在创伤后或在神经变性过程中增强神经元存活 疾病
英文摘要
DESCRIPTION (Adapted from applicant's abstract): Nerve growth factor (NGF) is a protein required for the development, maintenance, and repair of the nervous system. There are two NGF receptors, gp75 and the tyrosine kinase TrkA. Both of these receptors can signal separately and they synergize with each other to activate multiple signal transduction pathways. The investigators hypothesize that NGF-induced receptor dimerization and clustering are the initiating These studies may provide a physical basis for NGF receptor signaling and, thereby, aid the development of new approaches for enhancing neuronal survival following trauma or during neurodegenerative disease.
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  • 批准号：
    6791620
  • 项目类别：
  • 资助金额：
    $47.89万
  • 财政年份：
    2004
  • 负责人：
    David E. Wolf
  • 依托单位：
    SENSOR TECHNOLOGIES, INC.
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