Endocardial sprouting and mechano-signalling in heart trabeculation

该项目旨在了解心室，哺乳动物心脏的泵室，如何在胚胎生命期间形成。关键是小梁的精细化，小梁是在心室壁的内表面上形成海绵状层的心肌突起，在收缩、氧气和营养交换、传导和分隔中发挥重要作用。该项目预计将使用高分辨率，单细胞方法对小梁形成有更深入的了解，并研究收缩或血流的生物机械力如何影响室的形成。

This project aims to understand how the ventricles, the pumping chambers of the mammalian heart, form during embryonic life. Critical is the elaboration of trabeculae, myocardial projections that form a sponge-like layer on the inner surface of the chamber wall and which play vital roles in contraction, oxygen and nutrient exchange, conduction and septation. The project expects to develop a deeper understanding of trabeculation using high resolution, single cell methodologies, and to investigate how bio-mechanical forces from contraction or blood flow influence chambers formation.