DOPPLER ULTRASOUND VENOUS EMBOLI MONITOR

深静脉栓子（血凝块）引起的肺栓塞（PE） 血栓形成（DVT）是健康成人死亡的主要原因， 许多发生在没有临床警告的情况下， “沉默的杀手”在临床实践中，非常需要一种无人值守的 用于检测静脉栓塞的器械。 多普勒超声的表现能力，特别是检测 微栓子将是构建一种新工具的基础， 并具有成本效益地识别有PE风险的个体，这将： 静脉循环中的微栓子，指导治疗措施， 确定其有效性。 在第一阶段，设计并构造了双选通多普勒， 用于证明人群中25%的微栓子患病率 20例确诊DVT的患者。80%的患者出现微栓子 接受肝素治疗一天或更短时间 在第二阶段，一种新的设备，具有增强功能，便于定位 将构建肺动脉或股静脉并用于确定 在一系列表现为高血压的患者中， DVT风险。 第二阶段的结果将用于设计第三阶段的设计， 预期的商业市场。 拟议的商业应用： 该项目将导致一个独特的商业工具， 监测是否存在有形成分栓塞的市场潜力 深静脉血栓形成的静脉循环， 肺栓塞（PE）。一旦发现，抗凝治疗可以 由医生管理，以预防或降低PE风险。其他市场 并且应用包括用于潜水员中的减压气泡的监测器， 飞行员和宇航员，神经外科栓塞，整形外科， 四肢骨折

Pulmonary embolism (PE) caused by emboli (blood clots) from deep venus thrombosis (DVT) is a major cause of death in otherwise healthy adults, many occurring without clinical warning and earning PE the reputation as "silent killer". Great need exists in clinical practice for an unattended device to detect venous embolization. The demonstrated capability of Doppler ultrasound to detect particularly microemboli will be the basis for constructing a new tool to accurately and cost effectively identify individuals at risk of PE which will: detect microemboli in the venous circulation, guide therapeutic measures, and determine their effectiveness. In Phase I a dual-gate Doppler was designed and constructed, and then was used to demonstrate a 25% prevalence rate of microemboli in a population of 20 patients with confirmed DVT. 80% of patients presenting microemboli had been on heparin therapy for a day or less. In Phase II, a novel device with enhancements for easy location of the pulmonary artery or femoral vein will be constructed and used to determine prevalence of microemboli in a series of patients presenting with high risk for DVT. Phase II results will be used to design a Phase III devise for the large anticipated commercial market. Proposed commercial applications: The project will lead to a unique commercial instrument with a large market potential to monitor for the presence of formed element emboli in the venous circulation from deep venous thrombosis, a major cause of pulmonary embolism (PE). Once detected, anticoagulant therapy can be administered by physicians to prevent or reduce the risk PE. Other markets and applications include a monitor for decompression bubble in divers, pilots and astronauts, embolism in neurosurgery, orthopedic surgery, and fractures of extremities.