NOVEL STRATEGY FOR BIOSUBSTRATE PROTEIN KINASE INHIBITOR

描述(改编自应用程序)：蛋白激酶在 许多细胞信号通路，并增强了蛋白激酶的活性 与癌症和其他增殖性疾病有牵连。特异性抑制剂 将允许选择性地调节细胞生长机制，因此，可以 成为潜在有用的癌症疗法。这个项目的总体目标是 发现新一类有效和特异的个体抑制物 丝氨酸/苏氨酸和酪氨酸蛋白激酶。申请人建议： 用双管齐下的组合、过渡态模拟来解决这个问题 开发高效双琥珀酸类抑制剂的战略。 建议的商业应用：不可用

DESCRIPTION (Adapted from the application): Protein kinases play key roles in many cell signaling pathways, and enhanced activity of the protein kinases has been implicated in cancer and other proliferative diseases. Specific inhibitors would allow selective regulation of cell growth mechanisms and therefore, may be potentially useful cancer therapeutics. The overall goal of this project is to discover new classes of potent and specific inhibitors of individual serine/threonine and tyrosine protein kinases. The applicant proposes to approach this problem with a two-pronged combinatorial, transition state analog strategy to develop highly potent bisubstrate inhibitors. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE