TYPE I COLLAGEN MATRIX REFERENCE MATERIALS FOR TISSUES

描述(摘自申请者摘要)：组织工程学是一种 生物学、物理学、工程学和生物科学的交叉学科 医药。组织工程产品的三个关键组成部分(或 工程组织产品)是细胞外基质、细胞和 调节信号(组织特异性诱导因子和/或生长 因素)。为了对这些组成部分进行系统有效的评估 方式，研究人员提议为组织工程学社区提供 用一系列I型胶原基质标准物质 工程研究。在I期，一系列I型胶原基质 将设计和开发参考材料。它们包括漏洞百出、 已定义的管状、膜状、细丝和纤维基质 适用于各种组织的特性和特性 以及器官修复和再生组织工程产品的研究和 发展。在第二阶段，这些矩阵将在#年制造和测试 与特定组织相关的各种类型的细胞的体外培养 再生应用程序。最先进的破损修复技术 组织或器官是由组织工程产品制成的，可以使用 替换或纠正人体中功能不佳的组件或 在这些生命系统中引入更好的功能组件。这个 组织基质标准物质的引入将大大方便 组织工程产品开发。调查人员预计 组织基质标准物质在生物医学领域的广泛应用 组织工程产品研发。因此，商业广告 标准物质的价值被清楚地识别出来。 建议的商业应用：不可用

DESCRIPTION (adapted from applicant's abstract): Tissue engineering is an interdisciplinary science of biology, physical sciences, engineering and medicine. The three key components of tissue engineering products (or engineered tissue products) are the extracellular matrix, the cells and the regulatory signals (tissue specific induction factor and/or growth factors). I order to effectively evaluate these components in a systematic way, the investigators propose to provide the tissue engineering community with a series of type I collagen matrix reference materials for engineering research. In phase I, a series of type I collagen matrix reference materials will be designed and developed. They include porous, tubular, membrane, filament, and fibrillar matrices of defined characteristics and properties that are suitable for a variety of tissue and organ repair and regeneration tissue engineering product research and development. In phase II, these matrices will be fabricated and tested in vitro with various types of cells that are pertinent for particular tissue regeneration applications. The state-of-the-art of repair of damaged tissue or organ is by tissue engineering products, which can be used either to replace or correct poorly functional components in humans or to introduce better functional components into these living systems. The introduction of tissue matrix reference materials will greatly facilitate the tissue engineering product development. The investigators anticipate a wide range of applications of the tissue matrix reference materials in tissue engineering product research and development. Thus, the commercial value of the reference materials is clearly identified. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE