BLADDER AFFERENT NEURON RESPONSIVENESS

这个新项目建议研究修改的反应， 膀胱传入神经元产生的自主神经系统和 部分去神经支配对这些影响的后果。 目的是 检查骨盆区域的神经损伤可能导致 影响感觉纤维的神经病。 待审查的问题： 部分去神经支配导致其余神经系统的特征改变， 还是膀胱的再生传入神经 研究 提出了一个系统的调查范围内的特点传入 纤维兴奋的膀胱扩张，以确定是否 这种传入单位的一个子集是专门的伤害感受器。 一个主要 这项研究的动力来自于感觉症状的突出， 间质性膀胱炎综合征及其常见病 可能遭受骨盆结构创伤的人。 将在大鼠中检查膀胱传入单位特征， 与定量膀胱测压相关。 刺激的影响 自主传出神经膀胱和自主化学 介质（去甲肾上腺素、SP、VIP、神经肽γ、胆碱能、ATP 类似物）对这种传入特性的影响。 的影响 由于腹下肌损伤导致部分去神经支配， 盆神经或交感神经对感觉器官的自主调节 特性将被评估。 这些关于感觉器官的新奇信息 膀胱和修改其特征下， 与临床条件平行的情况应提供重要的 间质性膀胱炎和其他膀胱炎的病因 可能是神经性内脏紊乱

This new project proposes to study modifications of the responsiveness of bladder afferent neurons produced by the autonomic nervous system and the consequences of partial denervation upon these effects. The purpose is to examine the possibility that neural trauma in the pelvic region can lead to a neuropathy affecting sensory fibers. The question to be examined: does partial denervation lead to alterations in characteristics of the remaining or regenerated afferents supplying tahe urinary bladder? The study proposes a systematic survey of the range of characteristics of afferent fibers excited by distension of the bladder in order to determine whether a subset of such afferent units are specialized nociceptors. A major impetus for the study comes from the prominence of sensory symptoms in the syndrome of interstitial cystitis and the syndrome's common occurrence in persons who may have suffered traumatic injury of pelvic structures. Bladder afferent unit characteristics will be examined in rats in association with quantitative cystometrograms. Effects of stimulation of autonomic efferent nerves to the bladder and of autonomic chemical mediators (norepinephrine, SP, VIP, neuropeptide gamma, cholinergics, ATP analogues) on such afferent characteristics are to be studied. The effects of partial denervation as a consequence of injury of the hypogastric, pelvic or sympathetic nerves on the autonomic modulation of sense organ characteristics will be evaluated. Such novel information on sense organs of the bladder and modifications in their characteristics under circumstances paralleling clinical conditions should provide important insight into the etiology of interstitial cystitis and that of other possible neuropathic visceral disorders.