ANTITUMOR AND ANTIVIRAL NUCLEOSIDE ANALOGUES

描述：（改编自申请人摘要）新核苷和 将制备核苷酸类似物，并研究其作为抗病毒和 抗肿瘤剂。这些化合物将包括：（i）对映异构体 抗病毒亚甲基环丙烷核苷类似物，（ii）亲脂性 磷酸盐前药、磷酸盐和三磷酸盐 亚甲基环丙烷类似物，（iii）亚甲基环烷烃核苷 环丁烷、环戊烷和环己烷环系的类似物 和（iv）偕-二氟亚甲基环丙烷类似物。抗病毒作用 将在许多病毒试验中进行研究，包括人类和小鼠 巨细胞病毒（HCMV和MCMV），单纯疱疹病毒1型和2型 （HSV-1和HSV-2）和人类免疫缺陷（HIV）。体内活性和 还将研究活性化合物的作用机理。 选定的类似物也将作为潜在的抗肿瘤药物进行研究。

Description: (Adapted from Applicant's Abstract) New nucleoside and nucleotide analogues will be prepared and studies as antiviral and antitumor agents. These compounds will include: (i) enantiomeric antiviral methylenecyclopropane nucleoside analogues, (ii) lipophilic phosphate prodrugs, phosphonates and triphosphates of methylenecyclopropane analogues, (iii) methylenecycloalkane nucleoside analogues with cyclobutane, cyclopentane,and cyclohexane ring systems and (iv) gem-difluoromethylenecyclopropane analogues. Antiviral effects will be studied in a number of viral assays including human and murine cytomegalovirus (HCMV and MCMV), herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) and human immunodeficiency (HIV). In vivo activity and mechanism of action of active compounds will also be investigated. Selected analogues will also be studies as potential antitumor agents.