Neural migration: Which cells advance and which stay behind?

该项目旨在检查在发育中的肠道中定居的神经脊细胞，并确定为什么一些细胞前进，而另一些细胞则留在后面，以填充一个区域。定向细胞迁移对包括神经系统在内的正常发育是必不可少的。在迄今已分析的大多数迁移细胞群体中，所有细胞都作为一个集体从一个地点迁移到另一个地点。然而，也有一些迁徙细胞群体必须聚集在它们迁徙的区域，因此一些细胞被甩在后面，而另一些细胞则前进。计划中的数据很可能与其他细胞群体相关，这些细胞群体也存在于它们迁移的区域，包括神经脊源性黑素细胞和雪旺细胞前体细胞。

This project aims to examine the neural crest cells that colonise the developing gut and to identify why some cells advance while others stay behind to populate a region. Directed cell migration is essential for normal development, including for the nervous system. In most of the migratory cell populations that have been analysed to date, all of the cells migrate as a collective from one location to another. However, there are also migratory cell populations that must populate the areas through which they migrate, and thus some cells get left behind while others advance. The planned data are likely to be relevant to other cell populations that also populate the areas through which they migrate, including neural crest-derived melanocytes and Schwann cell precursors.