MODULATION OF BONE RESORPTION BY MECHANICAL STRESSES

描述（改编自研究者摘要）：本资助提案是 专门针对美国国立卫生研究院“学术研究提高奖”（区域 PA-97-052）。该提案确定了解决重大问题的战略， 颅面整形外科的问题，涉及到什么样的力量 移动颅面骨骼，以及如何最好地应用它们。申请人 寻求对试点研究的支持， 研究人员设计。本提案的总体目标是 确定是否具有某些特征的压缩循环力， 待确定（此处），比静态更有效地诱导骨吸收 压缩生长中的兔子颅面缝的力。工作范围 压缩循环力和静态力的参数将通过以下方式确定： 量化由以下因素引起的体内骨应变的大小、模式和速率 这些力量在兔子颅面骨中的作用。慢性负荷后， 选定的循环和静态力参数，骨轮廓的改变， 将通过标记定向头影测量确定矢状面尺寸 放射线照相术。在体内，颅面骨缝附近的骨应变将 确定，然后定量的活性染色的新骨形成， 组织形态学分析相同的缝线。拟议的研究是 预期不仅要确定颅面的反应特征， 骨骼的循环和静态力的选定参数，但也相关 颅面骨缝附近的机械应力与骨缝的量 骨吸收此外，预期的调查结果将构成以下方面的基础： 解决目前研究的长期目标， 一系列力参数对诱导骨吸收的影响 颅面骨

DESCRIPTION (adapted from the Investigator's abstract): This grant proposal is specifically addressed to the NIH "Academic Research Enhancement Award" (AREA PA-97-052). This proposal has identified strategies to address a significant problem in craniofacial orthopedics, what sorts of forces are involved in moving craniofacial bones, and how best they should be applied. The applicant seeks support for pilot research studies with methods the Principal Investigator has designed. The overall goal of the present proposal is to determine whether compressive cyclic forces with certain characteristics, yet to be determined (here), induce bone resorption more effectively than static forces that compress craniofacial sutures in growing rabbits. A working range of parameters of compressive cyclic and static forces will be determined by quantifying the magnitude, mode and rate of in vivo bone strain induced by these forces in rabbit craniofacial bones. Following chronic loading with selected cyclic and static force parameters, alteration of bone contour in the sagittal dimension will be determined by marker-orientated cephalometric radiography. In vivo bone strain adjacent to craniofacial sutures will be determined, followed by quantification of vital-stained new bone formation in the same sutures by histomorphometric analyses. The proposed studies are anticipated not only to determine the response characteristics of craniofacial bones to selected parameters of cyclic and static forces, but also to correlate mechanical stresses adjacent to craniofacial sutures with the amount of sutural bone resorption. In addition, the anticipated findings will form the basis of addressing the long-term goal of the present research to investigate the effects of a cascade of force parameters on inducing bone resorption in craniofacial bones.