MEETING ON TYROSINE PHOSPHORYLATION AND CELL SIGNALING

酪氨酰残基上蛋白质的磷酸化作用现在已被公认 是控制这种基本细胞的基本要素， 生长和增殖、分化、细胞骨架 功能和细胞周期。 我们目前正在目睹一场 在结构、监管和 蛋白质酪氨酸激酶（PTKs）和蛋白质酪氨酸 磷酸酶（PTPs），其协调作用决定了 细胞磷酸酪氨酸。 第五次会议的目标是： "酪氨酸磷酸化和细胞信号传导"是为了提供一个 PTK和PTPs的研究将被整合，以帮助 参与者看到他们的结果如何有助于整体"大 picture. "我们将根据生理学和心理学的 过程和细胞功能，而不是围绕特定的 酶的种类，以便尝试并提供生物背景。 除了Lew Cantley和Ernst的主题演讲之外， 所有发言者将从提交的摘要中选出。 这 将重点放在鼓励研究生， 博士后和年轻的独立调查员来演讲。 它 还应便于介绍最新和"最热"的 结果 我们预计将有300 - 350人参加，其中约 60人将作口头介绍，多达160人将展示海报。 的 本提案中要求的资金将使更多的年轻调查员 参与，特别是那些还没有独立 经费 我们希望PTKs和PTPs的研究能在此基础上得到整合 会议，重点放在这些酶的生物作用，将 在整个外地产生一种凝聚力和沟通感。

The phosphorylation of proteins on tyrosyl residues is now recognized to be an essential element in the control of such fundamental cellular processes as growth and proliferation, differentiation, cytoskeletal function and the cell cycle. We are currently witnessing an outstanding period of progress in characterizing the structure, regulation and function of both protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), the coordinated action of which governs the levels of cellular phosphotyrosine. The objective of this Fifth Meeting on "Tyrosine Phosphorylation and Cellular Signalling" is to provide a format in which the study of PTKs and PTPs will be integrated to help participants see how their results contribute to the overall "big picture." We will organize the sessions based around physiological processes and cellular functions, rather than around particular categories of enzymes, so as to try and provide a biological context. With the exception of the Keynote Addresses by Lew Cantley and Ernst Hafen, all speakers will be selected from submitted abstracts. This will allow emphasis to be placed on encouraging graduate students, postdocs and young independent investigators to present the talks. It also should facilitate the presentation of the most recent and "hottest" results. We anticipate an attendance of 300-350 of which approximately 60 will give oral presentations and up to 160 will present posters. The funds requested in this proposal will enable more young investigators to participate, especially those who do not yet have independent funding. We hope that the integration of research on PTKs and PTPs at this meeting, placing emphasis on the biological roles of these enzymes, will engender a sense of cohesiveness and communication across the field.