MRI EVALUATION OF THE EFFECTS OF CORONARY ARTERY DISEASE

冠状动脉疾病（CAD）是一个主要的公共卫生问题;目前 评价CAD中心脏的常规成像方法具有许多 局限性。 心脏的磁共振成像（MRI）具有很大的 改善CAD诊断和管理的潜力，但需要 进一步发展和评价。 的长期目标 本申请中提出的工作是产生一种改进的、临床上 MRI评价CAD的实用方法，并证明其 效用 具体目标是：1）开发改进的MRI 灌注成像和分析技术，并将其整合到一个 全面的心脏MRI检查，2）这些MRI的验证 技术在慢性心肌缺血的动物模型中，和3） 初步评价这些技术在一系列人类心脏 患者 心脏成像方法的技术发展将包括 快速灌注成像的发展（通过快速成像的 MR造影剂团的第一次通过）和组织 表征MRI技术，以及它们与先前 开发了区域功能MRI技术（使用空间标记 磁化调制（SPAMM））。 相应的图像分析 计划将在以前开发的计划中开发， 标记的MR图像分析，SPAMMVU。 数据可视化程序将 既要有助于研究的主要解释， 将分析结果传达给转诊临床医生。 这些 成像和分析技术将在猪模型中得到验证， 慢性缺血，包括独立的灌注测量， 微球 人类研究将包括正常受试者和 有限的CAD患者系列;这将使我们能够进行 初步评价这些MRI方法在CAD中的有用性， 计划进行更明确的评估。 MRI研究的结果 将与常规放射性核素成像研究进行比较， 患者的临床表现。

Coronary artery disease (CAD) is a major public health problem; current conventional imaging methods to evaluate the heart in CAD have many limitations. Magnetic resonance imaging (MRI) of the heart has great potential to improve the diagnosis and management of CAD, but it needs further development and evaluation. The long term objectives of the work proposed in this application are to produce an improved, clinically practical method for MRI evaluation of CAD and to demonstrate its utility. The specific aims are: 1) development of improved MRI perfusion imaging and analysis techniques and their integration into a comprehensive cardiac MRI examination, 2) validation of these MRI techniques in an animal model of chronic myocardial ischemia, and 3) preliminary evaluation of these techniques in a series of human cardiac patients. The technical development of cardiac imaging methods will include development of rapid perfusion imaging (through rapid imaging of the first passage of a bolus of MR contrast agent) and tissue characterization MRI techniques, and their integration with previously developed regional function MRI techniques (using tagging with spatial modulation of magnetization (SPAMM)). The corresponding image analysis programs will be developed within a program previously developed for the analysis of tagged MR images, SPAMMVU. Data visualization programs will be developed both to aid the primary interpretation of the study and to convey the results of the analysis to the referring clinician. These imaging and analysis techniques will be validated in a porcine model of chronic ischemia, including independent perfusion measurement with microspheres. Human studies will include both normal subjects and a limited series of patients with CAD; this will enable us to perform an initial evaluation of the usefulness of these MRI methods in CAD and to plan for a more definitive evaluation. The results of the MRI studies will be compared with both conventional radionuclide imaging studies and the patient's clinical course.