ENDOCRINE ASPECTS OF HUMAN NEOPLASIA

这项卓越的内分泌学研究计划旨在 将研究工作整合到内分泌方面的研究中 人类肿瘤。这五个组成部分项目包括：1. 甲状旁腺激素相关人类肿瘤蛋白的内分泌学； 2.人类淋巴瘤的维生素D内分泌系统；3.肿瘤 人类甲状腺肿瘤中的抑癌基因；4.人甲状腺肿瘤的作用机制 垂体肿瘤发生；5.人卵巢癌与P53。三 核心单位将为这些项目提供专家多学科支持 项目。它们包括管理、实验室和 细胞遗传学核心实验室。 这个项目带来了一个多学科的研究方法。 肿瘤和副肿瘤的基本机制 内分泌综合征。这些研究项目的协同效应将 提供基本的细胞和分子洞察力 内分泌肿瘤患者的病理生理及治疗 器官(甲状腺、垂体和卵巢)和由以下原因引起的综合征 非内分泌肿瘤对内分泌产物的异常分泌 (高钙血症和恶病质)。这将导致进一步 对内分泌功能紊乱之间联系的认识 以及内分泌和内分泌同时存在的患者的肿瘤过程 非内分泌肿瘤。

This Program of Excellence in Endocrinology Research aims to integrate research efforts into the study of endocrine aspects of human neoplasia. The five component projects include: 1. Endocrinology of a parathyroid-hormone-related human tumor protein; 2. Vitamin D endocrine system in human lymphoma; 3. Tumor suppressor genes in human thyroid neoplasms; 4. Mechanisms of human pituitary tumorigenesis; 5. Human ovarian cancer and p53. Three core units will provide expert multidisciplinary support to these projects. They include Administration, Laboratory, and Cytogenetics Core Laboratories. This program brings a multidisciplinary approach to study fundamental mechanisms involved in neoplastic and paraneoplastic endocrine syndromes. The synergism of these research projects will provide basic cellular and molecular insights into the pathophysiology and management of patients with tumors of endocrine organs (thyroid pituitary and ovary), and of syndromes caused by abnormal elaboration of endocrine products by non-endocrine tumors (hypercalcemia and cachexia). This will lead to further understanding of the linkage between disordered endocrine function and the neoplastic process in patients harboring both endocrine and non-endocrine tumors.