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CELLULAR IMMUNE RESPONSES TO CMV IN COGNEITAL AND PERINATAL INFECTIONS

CELLULAR IMMUNE RESPONSES TO CMV IN COGNEITAL AND PERINATAL INFECTIONS
认知和围产期感染中 CMV 的细胞免疫反应
批准号：
3857357
负责人：
ROBERT F PASS
金额：
$0.0万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3857357
关键词：
Herpesviridae disease cell mediated cytotoxicity cellular immunity congenital infection cytomegalovirus enzyme linked immunosorbent assay female flow cytometry helper T lymphocyte human pregnant subject human subject humoral immunity immunofluorescence technique immunosuppression interferons interleukin 1 interleukin 2 leukocyte activation /transformation longitudinal human study lymphocyte microorganism culture microorganism immunology monoclonal antibody newborn human (0-6 weeks) nucleic acid hybridization nucleic acid probes perinatal pregnancy immunology pregnancy infection puerperal infection radioimmunoassay serology /serodiagnosis suppressor T lymphocyte tissue /cell culture virus antigen virus cytopathogenic effect virus infection mechanism

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中文摘要
翻译
该项目的目的是通过进一步定义 人体特定细胞的纵向研究 先天性巨细胞病毒感染患者的免疫应答 在怀孕期间和产后期间对年轻妇女的影响。在……里面 在前一组中，我们将检验这样的假设 与特定的细胞免疫有关 持续感染和进展性疾病的发生 恶化。在后一组(母亲)中，我们将确定 用抗原来衡量特定细胞是否介导了免疫 刺激淋巴因子的产生与巨细胞病毒特异性应答 细胞频率是病毒排泄的重要决定因素 孕期和产后间歇期或传播期间 将CMV传给后代。
英文摘要
The purpose of this project is to further define through longitudinal study of human subjects the specific cellular immune responses of patients with congenital CMV infection and of young women during pregnancy and the postpartum period. In the former group we will examine the hypothesis that alterations of specific cellular immunity are associated with both the persistence of infection and occurrence of progressive deterioration. In the latter group (mothers) we will determine whether specific cell mediated immunity as measured by antigen stimulated lymphokine production and CMV specific responder cell frequency is a significant determinant of virus excretion during pregnancy and the postpartum interval or of transmission of CMV to offspring.
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ADOLESCENT PREGNANCY AND CONGENITAL CYTOMEGALOVIRUS INFECTION
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CELLULAR IMMUNE RESPONSES TO CMV IN COGNEITAL AND PERINATAL INFECTIONS
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