DIMENSIONS OF AGING--GENETIC AND EVIRONMENTAL INFLUENCE

本提案请求支持继续执行由 计划项目赠款(AG 04948)。这项研究使用了一个系统的 派生和维持遗传异质性的小鼠种群 纵向和横截面相结合的设计，覆盖了寿命 动物的生命。动物将根据各种与年龄相关的指标进行测量 与老年学相关的多个领域的表型。这些措施包括 行为、自由基、动态平衡、免疫学、病理学和生理学。 多变量分析将检验结构关系 这些领域内和之间的变量，以及正在发生的变化 超过时间顺序的年龄，并将用于生存分析。 这项纵向研究涉及两代家庭。量化 基于亲子关系、兄弟姐妹关系的遗传分析 表亲、阿姨/叔叔和侄女/侄女将产生对基因的估计 和环境对个体差异的贡献 从多变量分析得到的表型和线性组合， 以及这些单一和复合表型的寿命变化。

This proposal requests support for a continuation of a project initiated by a Program Project grant (AG 04948). The study utilizes a systematically derived and maintained genetically heterogeneous stock of mice in a combined longitudinal and cross-sectional design which covers the lifespan of the animals. Animals will be measured on a wide variety of age-related phenotypes from a number of domains relevant to gerontology. These include behavior, free-radicals, homeostasis, immunology, pathology and physiology. Multivariate analyses will examine the structural relationships among variables within and between these domains, and in changes taking place over chronological age, and will be employed in survival analyses. The longitudinal study involves two-generation families. Quantitative genetic analyses based on relationships of parent and offspring, siblings, cousins, aunt/uncle and niece/nephew will generate estimates of the genetic and environmental contributions to the variances of the individual phenotypes and to linear composites derived from the multivariate analyses, and to the lifespan changes in these single and composite phenotypes.