THE SYNTHESIS OF ROSARAMYCIN AND RELATED SYSTEMS

这项赠款的具体目标包括两个总的综合， 这些实验室三年前开发的羟醛化学。 这 该方法利用了烯醇化物体系的化学性质， 葡萄酒 这些合成目标中的第一个是 大环内酯类抗生素罗萨霉素（1），一个相当大的分子系统， 生物兴趣。 我们对这种分子的合成工作已经进行到第三阶段了 年 实验设计的进展报告和第一部分， 本建议的方法部分将讨论这一现状 问题和我们打算在这方面作出的努力。 该建议的第二部分涉及开环酸的构建 红霉素（2）。 在本节中，我们将提出一个详细的研究， 我们打算采用沿着的综合方法， 合成路线本身的描述。

The specific aims of this grant include two total syntheses which are based on aldol chemistry developed in these laboratories three years ago. This methodology utilizes the chemistry of enolate systems arising from vinylogous urethanes. The first of these synthetic targets is the macrolide antibiotic rosaramycin (1), a molecular system of considerable biological interest. Our synthetic effort on this molecule is in its third year. The progress report and first part of the experimental design and methods section of this proposal will discuss the current status of this problem and our intended future efforts on it, respectively. The second part of this proposal involves a construction of the seco-acid of erythromycin (2). In this section, we will propose a detailed study of the methodology we intend to employ for the synthesis along with a description of the synthetic route itself.