TEMPORAL BIOMECHANICS OF HEALING IN SPINAL INJURIES

脊柱创伤是致残性损伤的主要原因。 治疗 这些损伤取决于相关的神经系统因素， 受伤以及脊柱是否被认为是“不稳定”。 最 治疗往往取决于后一点。 虽然这些都是一些 临床不稳定性评估的文献公认标准， 它们仅适用于急性评价，不考虑正在进行的生物学 愈合和适应的过程。 因此，目前我们没有能力 评估向延迟稳定或不稳定的时间进展。 我们建议研究颈椎损伤的愈合情况，作为一种 时间函数，长达六个月，使用犬模型。 体外 “稳定”及“不稳定”的定义将首先确立。 然后将这些信息用于体内模型中，以产生三个 不同程度的伤害和伪装 同样在手术时， 将三个0.8 mm钢球植入受伤部位的椎骨中 上下各有一节椎骨。利用立体声技术 X线摄影和计算机数字化，颈椎的精确分析， 当愈合发生时，将在体内进行运动。 三维 稳定性分析以及受伤和假的力量测量 将在处死后的标本中进行脊柱检查。 除了单独分析每个数据集外， 类型也将获得。 体内稳定性试验将提供 关于一个人的愈合过程的连续生物力学信息， 同样的动物。 这将产生更好的临床相关标准 脊柱不稳的定义 体外密切相关 并且体内稳定性结果可以建议一种监测 脊柱结构 最后，功能性脊柱单位和个体韧带 力量分析将产生关于脊柱变化的数据， 组成部分，如椎骨和韧带，作为脊柱损伤的功能， 治愈时间

Trauma of the spine is a major cause of disabling injuries. The treatment of these injuries is dependent upon such factors as associated neurological injuries and whether or not the spine is considered "unstable". Most often, the treatment hinges on this latter point. Although these are some accepted criteria in the literature for assessment of clinical instability, they apply only to acute evaluation and do not consider ongoing biological processes of healing and adaptation. Thus, presently we have no ability to assess temporal progression either towards delayed stability or instability. We propose to investigate the healing of injury to the cervical spine as a function of time, up to six months, using a canine model. In vitro definition of "stable" and "unstable" injuries will first be established. This information will then be used in an in vivo model to produce three injuries of varying severity and a sham. Also at the time of surgery, three 0.8 mm steel ball will be implanted into vertebrae at the injury site and one vertebrae above and below it. Using the techniques of stereo radiography and computer digitization, precise analysis of cervical spinal motion will be done in vivo while healing occurs. Three dimensional stability analyses as well as strength measurements of injured and sham spines will be performed in specimens after sacrifice. Besides analyzing each data set individually, correlations with other data types will also be obtained. The in vivo stability testing will provide continuous biomechanical information about the healing process in one and the same animal. This will result in better clinically relevant criteria for the definition of spinal instability. Close correlation of in vitro and in vivo stability results could suggest a method to monitor healing of spinal structures. Finally, functional spinal unit and individual ligament strength analysis will yield data about the changes in the spinal column components, e.g. vertebrae and ligaments, as function of spinal injury and healing time.